Short- and Long-Term Outcomes of Patients Who Underwent the Arterial Switch Operation at Siriraj Hospital—Thailand’s Largest National Tertiary Referral Center

dc.contributor.authorHannarong J.
dc.contributor.authorTocharoenchok T.
dc.contributor.authorSriyoschati S.
dc.contributor.authorThongcharoen P.
dc.contributor.authorTantiwongkosri K.
dc.contributor.authorNitiyarom E.
dc.contributor.authorSubtaweesin T.
dc.contributor.correspondenceHannarong J.
dc.contributor.otherMahidol University
dc.date.accessioned2025-02-05T18:36:39Z
dc.date.available2025-02-05T18:36:39Z
dc.date.issued2025-01-01
dc.description.abstractObjective: The aim of this study was to assess the short- and long-term outcomes of patients who underwent the arterial switch operation (ASO) at Siriraj Hospital in Thailand, and to identify postoperative complications and factors that significantly affect patient survival. Materials and Methods: We retrospectively studied all patients with dextro-transposition of the great arteries and anatomic variants who underwent the ASO from January 1995 to December 2020. Twenty-year overall survival and 15-year freedom from reoperation/reintervention were estimated using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to identify factors independently associated with 30-day mortality. Results: Of the 171 patients included, there were 116 males (67.84%). The median (minimum, maximum) age at operation was 33.5 (3-4,499) days, and the median (minimum, maximum) bodyweight was 3.4 (2.2-44.9) kg. Most patients (115/171, 67.25%) had an intact ventricular septum, whereas 48/171 (28.07%), had ventricular septal defects. The typical coronary anatomic pattern (1LCx-2R) was found in 120 patients (70.1%). Early mortality was 8.7% ± 4.4%, and there was no late death up to 20 years postoperatively with a median follow-up of five years. Fifteen-year freedom from reoperation or reintervention was 85.7%. Atypical coronary pattern was an independent factor for survival with an adjusted hazard ratio of 5.1 (95% confidence interval: 1.22-21.4; P =.026). Conclusions: The results of this study revealed excellent short- and long-term outcomes of the ASO at our center. Atypical coronary anatomy was found to be the only factor that independently predicted 30-day mortality.
dc.identifier.citationWorld Journal for Pediatric and Congenital Heart Surgery (2025)
dc.identifier.doi10.1177/21501351241311264
dc.identifier.eissn2150136X
dc.identifier.issn21501351
dc.identifier.scopus2-s2.0-85216400229
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/104187
dc.rights.holderSCOPUS
dc.subjectMedicine
dc.titleShort- and Long-Term Outcomes of Patients Who Underwent the Arterial Switch Operation at Siriraj Hospital—Thailand’s Largest National Tertiary Referral Center
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85216400229&origin=inward
oaire.citation.titleWorld Journal for Pediatric and Congenital Heart Surgery
oairecerif.author.affiliationSiriraj Hospital
oairecerif.author.affiliationFaculty of Medicine, Thammasat University

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