Pregnancy outcomes among women affected with thalassemia traits
5
Issued Date
2023-02-01
Resource Type
ISSN
09320067
eISSN
14320711
Scopus ID
2-s2.0-85127224592
Pubmed ID
35347380
Journal Title
Archives of Gynecology and Obstetrics
Volume
307
Issue
2
Start Page
431
End Page
438
Rights Holder(s)
SCOPUS
Bibliographic Citation
Archives of Gynecology and Obstetrics Vol.307 No.2 (2023) , 431-438
Suggested Citation
Ruangvutilert P., Phatihattakorn C., Yaiyiam C., Panchalee T. Pregnancy outcomes among women affected with thalassemia traits. Archives of Gynecology and Obstetrics Vol.307 No.2 (2023) , 431-438. 438. doi:10.1007/s00404-022-06519-y Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85138
Title
Pregnancy outcomes among women affected with thalassemia traits
Author's Affiliation
Other Contributor(s)
Abstract
Objective: To compare the maternal and perinatal outcomes between a group of pregnant women diagnosed with thalassemia traits and normal controls. Study design: A retrospective cohort study was conducted on singleton pregnant women affected and unaffected by thalassemia traits who attended an antenatal care clinic and delivered in Siriraj Hospital. Thalassemia status for all subjects was diagnosed by hemoglobin typing and/or DNA analysis. Patient charts were reviewed from January 2007 to December 2018. The control participants were randomly selected from the same period, with a control–case ratio of around 1:1. Results: Overall, 1288 women with thalassemia traits (348 with α thal-1 trait, 424 with β thal trait and 516 with HbE trait) and 1305 women in the control group were recruited. Baseline characteristics of both groups were similar, with the exception that the hematocrit level in the first trimester in the thalassemia trait group was significantly lower than that in the control group (34.8 ± 3.4% VS 36.9 ± 3.0%; p < 0.001). The prevalence of pregnancy-induced hypertension (PIH) was higher in the thalassemia trait group, at 6.9% VS 4.7% in the control group; p = 0.018. When subgroups were analyzed between each thalassemia trait, the number of maternal anemias in the first and third trimester was higher for all thalassemia traits compared to the normal group. The β thal and HbE traits increased the risk of PIH, with a relative risk (RR) = 1.67 and 1.66, respectively. Conclusions: Thalassemia traits minimally but significantly increase the risk of hypertensive disorders and maternal anemia. In addition, physiological changes during pregnancy may worsen the severity of anemia in the pregnant women with thalassemia traits.