Effectiveness of Local Wound Infiltration with Morphine, Ketorolac, and Bupivacaine Compared to Bupivacaine Alone Following Tibial Osteotomy in Pediatric Patients: A Randomized Controlled Trial
Issued Date
2025-01-01
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-105007356128
Journal Title
Siriraj Medical Journal
Volume
77
Issue
5
Start Page
322
End Page
330
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.77 No.5 (2025) , 322-330
Suggested Citation
Musikachart P., Ariyawatkul T., Wongcharoenwatana J., Adulkasem N., Eamsobhana P. Effectiveness of Local Wound Infiltration with Morphine, Ketorolac, and Bupivacaine Compared to Bupivacaine Alone Following Tibial Osteotomy in Pediatric Patients: A Randomized Controlled Trial. Siriraj Medical Journal Vol.77 No.5 (2025) , 322-330. 330. doi:10.33192/smj.v77i5.271038 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110621
Title
Effectiveness of Local Wound Infiltration with Morphine, Ketorolac, and Bupivacaine Compared to Bupivacaine Alone Following Tibial Osteotomy in Pediatric Patients: A Randomized Controlled Trial
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Abstract
Objective: To compare postoperative pain in children receiving ketorolac plus morphine local wound infiltration as adjunct analgesic agents with bupivacaine for local wound infiltration following tibial osteotomy Materials and Methods: This randomized, double-blind, placebo-controlled trial included patients aged 7–15 years underwent tibial osteotomy. Participants were allocated into two groups. The combination group received wound infiltration with 0.5 ml/kg bupivacaine 0.25% and 0.5 mg/kg ketorolac and 0.05 mg/kg morphine, while the control group received bupivacaine alone before skin closure. Primary outcomes were Visual Analog Scale (VAS) pain scores measured every 4 hours during the first 48 hours after surgery. Secondary outcomes included morphine consumption and opioid-related complications. Results: Among the 48 patients included in the study, no significant differences were observed in postoperative VAS pain scores between the two groups at nearly all time points. The combination group showed a trend towards higher mean pain levels compared to the control group at almost every time point from 4-hour to 48-hours post-operation. The maximum mean postoperative pain level in both groups, at four hours, was higher in the combination group, with a maximum mean postoperative pain level of 2.1 vs. 1.9. Higher mean opioid use was noted in the combination group, with a mean of 0.04±0.08 mg/kg vs. 0.03±0.04, at 4–8 hours postoperatively. Also, the cumulative morphine dose was lower in the control group compared to the combination group. Conclusion: The addition of ketorolac and morphine to bupivacaine for wound infiltration did not reduce postoperative VAS pain scores or opioid consumption following tibial osteotomy in children.