Drug nanocrystals: Surface engineering and its applications in targeted delivery
10
Issued Date
2024-11-15
Resource Type
eISSN
25890042
Scopus ID
2-s2.0-85207369920
Journal Title
iScience
Volume
27
Issue
11
Rights Holder(s)
SCOPUS
Bibliographic Citation
iScience Vol.27 No.11 (2024)
Suggested Citation
Lhaglham P., Jiramonai L., Jia Y., Huang B., Huang Y., Gao X., Zhang J., Liang X.J., Zhu M. Drug nanocrystals: Surface engineering and its applications in targeted delivery. iScience Vol.27 No.11 (2024). doi:10.1016/j.isci.2024.111185 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/101860
Title
Drug nanocrystals: Surface engineering and its applications in targeted delivery
Corresponding Author(s)
Other Contributor(s)
Abstract
Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug bioavailability and treatment effectiveness. Recent advances in preparation techniques have facilitated research on drug surface properties, leading to valuable surface engineering strategies. Surface modification can stabilize drug nanocrystals, making them suitable for versatile drug delivery platforms. Functionalized ligands further enhance the potential for targeted delivery, enabling precision medicine. This review focuses on the surface engineering of drug nanocrystals, discussing various preparation methods, surface ligand design strategies, and their applications in targeted drug delivery, especially for cancer treatments. Finally, challenges and future directions are also discussed to promote the development of drug nanocrystals. The surface engineering of drug nanocrystals promises new opportunities for treating complex and chronic diseases while broadening the application of drug delivery systems.