A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study
Issued Date
2024-12-01
Resource Type
ISSN
14659921
eISSN
1465993X
Scopus ID
2-s2.0-85212694874
Journal Title
Respiratory Research
Volume
25
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Respiratory Research Vol.25 No.1 (2024)
Suggested Citation
Peñuelas O., del Campo-Albendea L., Morales-Quinteros L., Muriel A., Nin N., Thille A., Du B., Pinheiro B., Ríos F., Marín M.C., Maggiore S., Raymondos K., González M., Bersten A., Amin P., Cakar N., Suh G.Y., Abroug F., Jibaja M., Matamis D., Zeggwagh A.A., Sutherasan Y., Artigas A., Anzueto A., Esteban A., Frutos-Vivar F., Del Sorbo L. A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study. Respiratory Research Vol.25 No.1 (2024). doi:10.1186/s12931-024-03037-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102572
Title
A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study
Author(s)
Peñuelas O.
del Campo-Albendea L.
Morales-Quinteros L.
Muriel A.
Nin N.
Thille A.
Du B.
Pinheiro B.
Ríos F.
Marín M.C.
Maggiore S.
Raymondos K.
González M.
Bersten A.
Amin P.
Cakar N.
Suh G.Y.
Abroug F.
Jibaja M.
Matamis D.
Zeggwagh A.A.
Sutherasan Y.
Artigas A.
Anzueto A.
Esteban A.
Frutos-Vivar F.
Del Sorbo L.
del Campo-Albendea L.
Morales-Quinteros L.
Muriel A.
Nin N.
Thille A.
Du B.
Pinheiro B.
Ríos F.
Marín M.C.
Maggiore S.
Raymondos K.
González M.
Bersten A.
Amin P.
Cakar N.
Suh G.Y.
Abroug F.
Jibaja M.
Matamis D.
Zeggwagh A.A.
Sutherasan Y.
Artigas A.
Anzueto A.
Esteban A.
Frutos-Vivar F.
Del Sorbo L.
Author's Affiliation
Hospital Regional 1° de Octubre ISSSTE
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
CHU Fattouma-Bourguiba
Universidad Pontificia Bolivariana
Universidad de Alcalá
Hannover Medical School
Universitat Autònoma de Barcelona
Hospital Universitario Ramón y Cajal
Centre Hospitalier Universitaire de Poitiers
Samsung Medical Center, Sungkyunkwan university
Flinders University
Mohammed V University in Rabat
The University of Texas Health Science Center at San Antonio
Faculty of Medicine Ramathibodi Hospital, Mahidol University
University Health Network
Papageorgiou General Hospital
Hospital Universitari de Bellvitge
Bombay Hospital and Medical Research Centre
Peking Union Medical College Hospital
Koç Üniversitesi
Hospital Nacional Professor Dr. Alejandro Posadas
University of G. d'Annunzio Chieti and Pescara
Hospital Universitario de Getafe
Universidade Federal de Juiz de Fora
Hospital Español “Juan José Crottoggini”
Hospital de Especialidades Eugenio Espejo
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
CHU Fattouma-Bourguiba
Universidad Pontificia Bolivariana
Universidad de Alcalá
Hannover Medical School
Universitat Autònoma de Barcelona
Hospital Universitario Ramón y Cajal
Centre Hospitalier Universitaire de Poitiers
Samsung Medical Center, Sungkyunkwan university
Flinders University
Mohammed V University in Rabat
The University of Texas Health Science Center at San Antonio
Faculty of Medicine Ramathibodi Hospital, Mahidol University
University Health Network
Papageorgiou General Hospital
Hospital Universitari de Bellvitge
Bombay Hospital and Medical Research Centre
Peking Union Medical College Hospital
Koç Üniversitesi
Hospital Nacional Professor Dr. Alejandro Posadas
University of G. d'Annunzio Chieti and Pescara
Hospital Universitario de Getafe
Universidade Federal de Juiz de Fora
Hospital Español “Juan José Crottoggini”
Hospital de Especialidades Eugenio Espejo
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: The trend over time and across different geographical areas of outcomes and management with noninvasive ventilation or invasive mechanical ventilation in patients admitted for acute exacerbations of chronic obstructive pulmonary disease and treated with ventilatory support is unknown. The purpose of this study was to describe outcomes and identify variables associated with survival for patients admitted to an intensive care unit (ICU) with acute exacerbation of chronic obstructive pulmonary disease [aeCOPD] who received noninvasive or invasive mechanical ventilation worldwide. Methods: Retrospective, multi-national, and multicenter studies, including four observational cohort studies, were carried out in 1998, 2004, 2010, and 2016 for the VENTILAGROUP following the same methodology. Results: A total of 1,848 patients from 1,253 ICUs in 38 countries admitted for aeCOPD and need of ventilatory support were identified in the four study cohorts and included in the study. The overall incidence of aeCOPD as a cause for ventilatory support at ICU admission significantly decreased over time and varied widely according to the gross national income. The mortality of patients admitted to ICU for aeCOPD and ventilatory support significantly decreased over time regardless of the geographical area and gross national income; however, there is a remarkable variability in ICU mortality according to geographical area and gross national income. The use of NPPV as the first attempt at ventilatory support has significantly increased over time, with a parallel reduction of invasive mechanical ventilation regardless of gross national income. Conclusion: In this worldwide observational study, including four sequential cohorts of patients over 18 years from 1998 to 2016, the mortality of patients admitted to ICU for aeCOPD and ventilatory support significantly decreased regardless of the geographical area and gross national income. Future research will need to investigate the reason for the remarkable variability in ICU mortality according to the geographical area, gross national income, and methods to select patients for the appropriate ventilatory support.