Association of a Novel IgG3 Allele With Malaria in Children From the Sepik Region of Papua New Guinea
Issued Date
2025-10-15
Resource Type
eISSN
15376613
Scopus ID
2-s2.0-105018925696
Pubmed ID
40717585
Journal Title
Journal of Infectious Diseases
Volume
232
Issue
4
Start Page
e555
End Page
e564
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases Vol.232 No.4 (2025) , e555-e564
Suggested Citation
Saeed M., Aitken E.H., Naung M.T., Bourke C., Wu K.W., Longley R.J., Chung A.W., Damelang T., Kiniboro B., Mueller I., Rogerson S.J. Association of a Novel IgG3 Allele With Malaria in Children From the Sepik Region of Papua New Guinea. Journal of Infectious Diseases Vol.232 No.4 (2025) , e555-e564. e564. doi:10.1093/infdis/jiaf390 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112789
Title
Association of a Novel IgG3 Allele With Malaria in Children From the Sepik Region of Papua New Guinea
Corresponding Author(s)
Other Contributor(s)
Abstract
BACKGROUND: Susceptibility to malaria can be influenced by host genetic factors, including immune response genes. Antibodies against Plasmodium antigens are known to play an important role in protection from clinical disease. Polymorphisms in these antibodies may result in different functional properties that could provide protection from malaria. METHODS: Immunoglobulin G1 (IgG1) and immunoglobulin G3 (IgG3) alleles and IgG3 hinge region were investigated by polymerase chain reaction and Sanger sequencing in a longitudinal cohort of children aged 1-3 years (N = 203) from the East Sepik region of Papua New Guinea. Linear regression was used to investigate associations between immunoglobulin alleles and Plasmodium infections. RESULTS: Seventy-eight percent of the children were either heterozygous (n = 82 [40%]) or homozygous (n = 77 [38%]) for IGHG3*30 (G3m29), a novel IgG3 allele. G3m29 has a long hinge region of 4 exons. Significantly fewer Plasmodium spp infections were observed in children with the IGHG3*30 allele compared to children without the allele (β = -1.736 [95% confidence interval {CI}, -3.39, -.079]; P = .038). This effect was most noticeable for Plasmodium vivax asymptomatic infections as IGHG3*30 carriers had on average 1 fewer infection in the 18-month follow-up period compared with non-IGHG3*30 allele carriers (β = -1.06 [95% CI, -2.01, -.12]; P = .028). Additionally, IGHG3*30 allele carriers had significantly lower levels of IgG to P vivax vaccine candidate proteins compared to non-IGHG3*30 allele carriers. CONCLUSIONS: The IGHG3*30 allele is highly prevalent in the East Sepik region and is associated with fewer Plasmodium spp infections.