An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease
Issued Date
2024-01-01
Resource Type
ISSN
26666359
eISSN
26666340
Scopus ID
2-s2.0-85192309800
Pubmed ID
38677287
Journal Title
Med
Rights Holder(s)
SCOPUS
Bibliographic Citation
Med (2024)
Suggested Citation
Zhang L., El-Shabrawi M., Baur L.A., Byrne C.D., Targher G., Kehar M., Porta G., Lee W.S., Lefere S., Turan S., Alisi A., Weiss R., Faienza M.F., Ashraf A., Sundaram S.S., Srivastava A., De Bruyne R., Kang Y., Bacopoulou F., Zhou Y.H., Darma A., Lupsor-Platon M., Hamaguchi M., Misra A., Méndez-Sánchez N., Ng N.B.H., Marcus C., Staiano A.E., Waheed N., Alqahtani S.A., Giannini C., Ocama P., Nguyen M.H., Arias-Loste M.T., Ahmed M.R., Sebastiani G., Poovorawan Y., Al Mahtab M., Pericàs J.M., Reverbel da Silveira T., Hegyi P., Azaz A., Isa H.M., Lertudomphonwanit C., Farrag M.I., Nugud A.A.A., Du H.W., Qi K.M., Mouane N., Cheng X.R., Al Lawati T., Fagundes E.D.T., Ghazinyan H., Hadjipanayis A., Fan J.G., Gimiga N., Kamal N.M., Ștefănescu G., Hong L., Diaconescu S., Li M., George J., Zheng M.H. An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease. Med (2024). doi:10.1016/j.medj.2024.03.017 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98333
Title
An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease
Author(s)
Zhang L.
El-Shabrawi M.
Baur L.A.
Byrne C.D.
Targher G.
Kehar M.
Porta G.
Lee W.S.
Lefere S.
Turan S.
Alisi A.
Weiss R.
Faienza M.F.
Ashraf A.
Sundaram S.S.
Srivastava A.
De Bruyne R.
Kang Y.
Bacopoulou F.
Zhou Y.H.
Darma A.
Lupsor-Platon M.
Hamaguchi M.
Misra A.
Méndez-Sánchez N.
Ng N.B.H.
Marcus C.
Staiano A.E.
Waheed N.
Alqahtani S.A.
Giannini C.
Ocama P.
Nguyen M.H.
Arias-Loste M.T.
Ahmed M.R.
Sebastiani G.
Poovorawan Y.
Al Mahtab M.
Pericàs J.M.
Reverbel da Silveira T.
Hegyi P.
Azaz A.
Isa H.M.
Lertudomphonwanit C.
Farrag M.I.
Nugud A.A.A.
Du H.W.
Qi K.M.
Mouane N.
Cheng X.R.
Al Lawati T.
Fagundes E.D.T.
Ghazinyan H.
Hadjipanayis A.
Fan J.G.
Gimiga N.
Kamal N.M.
Ștefănescu G.
Hong L.
Diaconescu S.
Li M.
George J.
Zheng M.H.
El-Shabrawi M.
Baur L.A.
Byrne C.D.
Targher G.
Kehar M.
Porta G.
Lee W.S.
Lefere S.
Turan S.
Alisi A.
Weiss R.
Faienza M.F.
Ashraf A.
Sundaram S.S.
Srivastava A.
De Bruyne R.
Kang Y.
Bacopoulou F.
Zhou Y.H.
Darma A.
Lupsor-Platon M.
Hamaguchi M.
Misra A.
Méndez-Sánchez N.
Ng N.B.H.
Marcus C.
Staiano A.E.
Waheed N.
Alqahtani S.A.
Giannini C.
Ocama P.
Nguyen M.H.
Arias-Loste M.T.
Ahmed M.R.
Sebastiani G.
Poovorawan Y.
Al Mahtab M.
Pericàs J.M.
Reverbel da Silveira T.
Hegyi P.
Azaz A.
Isa H.M.
Lertudomphonwanit C.
Farrag M.I.
Nugud A.A.A.
Du H.W.
Qi K.M.
Mouane N.
Cheng X.R.
Al Lawati T.
Fagundes E.D.T.
Ghazinyan H.
Hadjipanayis A.
Fan J.G.
Gimiga N.
Kamal N.M.
Ștefănescu G.
Hong L.
Diaconescu S.
Li M.
George J.
Zheng M.H.
Author's Affiliation
Ramathibodi Hospital
Shaheed Zulfiqar Ali Bhutto Medical University
Graduate School of Medical Science
The First Bethune Hospital of Jilin University
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
The First Affiliated Hospital of Wenzhou Medical University
The University of Sydney School of Medicine
Vall d'Hebron Institut de Recerca
Ospedale Sacro Cuore Don Calabria
European University Cyprus
The University of Sydney School of Public Health
Arabian Gulf University
Diabetes Foundation (India), New Delhi
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Beijing Children's Hospital, Capital Medical University
Royal Hospital
School of Medicine, Makerere University College of Health Sciences
Sheikh Khalifa Medical City
Universitas Airlangga
Universitair Ziekenhuis Gent
School of Medicine
Universiteit Gent
Universidad Nacional Autónoma de México
National University Hospital
Universidade Federal de Minas Gerais
Universiti Malaya
NUS Yong Loo Lin School of Medicine
Universitatea de Medicina si Farmacie Grigore T. Popa din Iasi
The University of Sydney
University of Southampton, Faculty of Medicine
Shanghai Jiao Tong University
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Semmelweis Egyetem
Faculty of Medicine
Università degli studi di Bari Aldo Moro
UAB Department of Pediatrics
Technion - Israel Institute of Technology
Pennington Biomedical Research Center
Hospital Universitario Marqués de Valdecilla
Mohammed V University in Rabat
Children's Hospital of Eastern Ontario, Ottawa
IRCCS Ospedale Pediatrico Bambino Gesù
King Faisal Specialist Hospital and Research Centre
Stanford Healthcare
Al Hada Armed Forces Hospital
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Stanford University
Karolinska Institutet
University of Colorado Department of Pediatrics
Peking Union Medical College Hospital
Wenzhou Medical University
Bangabandhu Sheikh Mujib Medical University
University of Pécs Medical School
Yonsei University Wonju College of Medicine
Jiangnan University
Centre Universitaire de Santé McGill
Johns Hopkins Medicine
Hospital Sirio-Libanês
University of Electronic Science and Technology of China
Universitatea Titu Maiorescu
University of G. d'Annunzio Chieti and Pescara
Marmara Üniversitesi Tip Fakültesi
Faculty of Medicine, Chulalongkorn University
Università di Verona Scuola di Medicina e Chirurgia
University Hospital Southampton NHS Foundation Trust
Jahra Hospital
Nikomed Medical Center
”Prof. Dr. Octavian Fodor” Regional Institute of Gastroenterology and Hepatology
Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province
“St. Mary” Emergency Children’s Hospital
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition
Fortis-C-DOC Centre of Excellence for Diabetes
Obesity and Cholesterol Foundation (N-DOC)
Universidade Federal de Ciências da Saúde
Shaheed Zulfiqar Ali Bhutto Medical University
Graduate School of Medical Science
The First Bethune Hospital of Jilin University
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
The First Affiliated Hospital of Wenzhou Medical University
The University of Sydney School of Medicine
Vall d'Hebron Institut de Recerca
Ospedale Sacro Cuore Don Calabria
European University Cyprus
The University of Sydney School of Public Health
Arabian Gulf University
Diabetes Foundation (India), New Delhi
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Beijing Children's Hospital, Capital Medical University
Royal Hospital
School of Medicine, Makerere University College of Health Sciences
Sheikh Khalifa Medical City
Universitas Airlangga
Universitair Ziekenhuis Gent
School of Medicine
Universiteit Gent
Universidad Nacional Autónoma de México
National University Hospital
Universidade Federal de Minas Gerais
Universiti Malaya
NUS Yong Loo Lin School of Medicine
Universitatea de Medicina si Farmacie Grigore T. Popa din Iasi
The University of Sydney
University of Southampton, Faculty of Medicine
Shanghai Jiao Tong University
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Semmelweis Egyetem
Faculty of Medicine
Università degli studi di Bari Aldo Moro
UAB Department of Pediatrics
Technion - Israel Institute of Technology
Pennington Biomedical Research Center
Hospital Universitario Marqués de Valdecilla
Mohammed V University in Rabat
Children's Hospital of Eastern Ontario, Ottawa
IRCCS Ospedale Pediatrico Bambino Gesù
King Faisal Specialist Hospital and Research Centre
Stanford Healthcare
Al Hada Armed Forces Hospital
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Stanford University
Karolinska Institutet
University of Colorado Department of Pediatrics
Peking Union Medical College Hospital
Wenzhou Medical University
Bangabandhu Sheikh Mujib Medical University
University of Pécs Medical School
Yonsei University Wonju College of Medicine
Jiangnan University
Centre Universitaire de Santé McGill
Johns Hopkins Medicine
Hospital Sirio-Libanês
University of Electronic Science and Technology of China
Universitatea Titu Maiorescu
University of G. d'Annunzio Chieti and Pescara
Marmara Üniversitesi Tip Fakültesi
Faculty of Medicine, Chulalongkorn University
Università di Verona Scuola di Medicina e Chirurgia
University Hospital Southampton NHS Foundation Trust
Jahra Hospital
Nikomed Medical Center
”Prof. Dr. Octavian Fodor” Regional Institute of Gastroenterology and Hepatology
Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province
“St. Mary” Emergency Children’s Hospital
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition
Fortis-C-DOC Centre of Excellence for Diabetes
Obesity and Cholesterol Foundation (N-DOC)
Universidade Federal de Ciências da Saúde
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts. Methods: A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed various aspects of pediatric MAFLD, including epidemiology, mechanisms, screening, and management. Findings: In round 1, we received 65 surveys from 35 countries and analyzed these results, which informed us that 73.3% of respondents agreed with 20 draft statements while 23.8% agreed somewhat. The mean percentage of agreement or somewhat agreement increased to 80.85% and 15.75%, respectively, in round 2. The final statements covered a wide range of topics related to epidemiology, pathophysiology, and strategies for screening and managing pediatric MAFLD. Conclusions: The consensus statements and recommendations developed by an international expert panel serve to optimize clinical outcomes and improve the quality of life for children and adolescents with MAFLD. These findings emphasize the need for standardized approaches in diagnosing and treating pediatric MAFLD. Funding: This work was funded by the National Natural Science Foundation of China (82070588, 82370577), the National Key R&D Program of China (2023YFA1800801), National High Level Hospital Clinical Research Funding (2022-PUMCH-C-014), the Wuxi Taihu Talent Plan (DJTD202106), and the Medical Key Discipline Program of Wuxi Health Commission (ZDXK2021007).