Urinary exosomes: Diagnostic impact with a bioinformatic approach
Issued Date
2022-01-01
Resource Type
ISSN
00652423
eISSN
21629471
Scopus ID
2-s2.0-85141449889
Pubmed ID
36427912
Journal Title
Advances in Clinical Chemistry
Volume
111
Start Page
69
End Page
99
Rights Holder(s)
SCOPUS
Bibliographic Citation
Advances in Clinical Chemistry Vol.111 (2022) , 69-99
Suggested Citation
Perpetuo L., Ferreira R., Thongboonkerd V., Guedes S., Amado F., Vitorino R. Urinary exosomes: Diagnostic impact with a bioinformatic approach. Advances in Clinical Chemistry Vol.111 (2022) , 69-99. 99. doi:10.1016/bs.acc.2022.07.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83876
Title
Urinary exosomes: Diagnostic impact with a bioinformatic approach
Author's Affiliation
Other Contributor(s)
Abstract
Exosomes are tiny membrane-enveloped vesicles of endosomal origin, typically 40–120 nm in diameter, produced by most cells in both normal and pathological situations. These exosomes can be isolated from all biofluids, including urine. In this context, many researchers have focused on the analysis of urinary exosomes because urine can be collected in large quantities, regularly, and with minimal effort. Exosomes contain phospholipids, cholesterol, proteins, glycoconjugates, nucleic acids, and metabolites. Because all organs and tissues produce exosomes, their molecular cargo can provide first-hand information about the physiological and biological state of the site of origin. Many potential disease biomarker candidates have already been identified in urinary exosomes. In this chapter, we performed a bibliometric analysis of the keywords “exosome(s)” and “urine” to identify related terms, diseases and molecular/biological processes, and other related terms. This yielded interesting results suggesting that exosomes in urine may play a role in the pathogenesis of various diseases. Moreover, this chapter discusses exosomes isolation and characterization methodologies and highlight the importance of urinary exosomes and their role in the diagnosis, prognosis and therapy of various diseases. We offer a bibliometric approach and an in-depth analysis on several exosomes' isolation techniques, diagnostic potential for urogenital and specific non-urogenital diseases, as well as an overview of miRNAs significance on urinary exosomes, conferring a more complete status to this review, something that was still lacking in the current literature.
