Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?
Issued Date
2024-01-01
Resource Type
ISSN
14714922
eISSN
14715007
Scopus ID
2-s2.0-85205437396
Journal Title
Trends in Parasitology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Trends in Parasitology (2024)
Suggested Citation
Kucharski M., Nayak S., Gendrot M., Dondorp A.M., Bozdech Z. Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?. Trends in Parasitology (2024). doi:10.1016/j.pt.2024.09.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101545
Title
Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?
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Corresponding Author(s)
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Abstract
The genetics of Plasmodium as an intracellular, mostly haploid, sexually reproducing, eukaryotic organism with a complex life cycle, presents unprecedented challenges in studying drug resistance. This article summarizes current knowledge on the genetic basis of artemisinin resistance (AR) – a main component of current drug therapies for falciparum malaria. Although centered on nonsynonymous single-nucleotide polymorphisms (nsSNPs), we describe multifaceted resistance mechanisms as part of a complex, cumulative genetic trait that involves regulation of expression by a wide array of polymorphisms in noncoding regions. These genetic variations alter transcriptome profiles linked to Plasmodium's development and population dynamics, ultimately influencing the emergence and spread of the resistance.
