Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis
Issued Date
2023-08-18
Resource Type
eISSN
25890042
Scopus ID
2-s2.0-85165349820
Journal Title
iScience
Volume
26
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
iScience Vol.26 No.8 (2023)
Suggested Citation
Preechanukul A., Kronsteiner B., Saiprom N., Rochaikun K., Moonmueangsan B., Phunpang R., Ottiwet O., Kongphrai Y., Wapee S., Chotivanich K., Morakot C., Janon R., Dunachie S.J., Chantratita N. Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis. iScience Vol.26 No.8 (2023). doi:10.1016/j.isci.2023.107234 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88248
Title
Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis
Other Contributor(s)
Abstract
NK cells are endowed with immunological memory to a range of pathogens but the development of NK cell memory in bacterial infections remains elusive. Here, we establish an assay inducing memory-like NK cell response to Burkholderia pseudomallei, the causative agent of the severe bacterial disease called melioidosis, and explore NK cell memory in a melioidosis patient cohort. We show that NK cells require bacteria-primed monocytes to acquire memory-like properties, demonstrated by bacteria-specific responses, features that strongly associate with CD160 expression. Induction of this memory-like NK cell is partly dependent on CD160 and IL-12R. Importantly, CD160 expression identifies memory-like NK cells in a cohort of recovered melioidosis patients with heightened responses maintained at least 3 months post hospital admission and reduced numbers of this cell population independently correlate with recurrent melioidosis. These newly identified memory-like NK cells are a promising target for future vaccine design and for monitoring protection against infection.