A Potential New Source of Therapeutic Agents for the Treatment of Mucocutaneous Leishmaniasis: The Essential Oil of Rhaphiodon echinus
Issued Date
2022-04-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85127836610
Pubmed ID
35408565
Journal Title
Molecules
Volume
27
Issue
7
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.27 No.7 (2022)
Suggested Citation
Oliveira C.V.B., da Silva P.A.G., Tintino S.R., Coronel C.C., Gomez M.C.V., Rolón M., da Cunha F.A.B., Morais-Braga M.F.B., Coutinho H.D.M., Siyadatpanah A., Wilairatana P., Kamdem J.P., Barros L.M., Duarte A.E., Pereira P.S. A Potential New Source of Therapeutic Agents for the Treatment of Mucocutaneous Leishmaniasis: The Essential Oil of Rhaphiodon echinus. Molecules Vol.27 No.7 (2022). doi:10.3390/molecules27072169 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83777
Title
A Potential New Source of Therapeutic Agents for the Treatment of Mucocutaneous Leishmaniasis: The Essential Oil of Rhaphiodon echinus
Other Contributor(s)
Abstract
Weeds are an important source of natural products; with promising biological activity. This study investigated the anti-kinetoplastida potential (in vitro) to evaluate the cytotoxicity in vitro) and antioxidant capacity of the essential oil of Rhaphiodon echinus (EORe), which is an infesting plant species. The essential oil was analyzed by GC/MS. The antioxidant capacity was evaluated by reduction of the DPPH radical and Fe3+ ion. The clone Trypanosoma cruzi CL-B5 was used to search for anti-epimastigote activity. Antileishmanial activity was determined using promastigotes of Leishmania braziliensis (MHOM/CW/88/UA301). NCTC 929 fibroblasts were used for the cytotoxicity test. The results showed that the main constituent of the essential oil was γ-elemene. No relevant effect was observed concerning the ability to reduce the DPPH radical; only at the concentration of 480 µg/mL did the essential oil demonstrate a high reduction of Fe3+ power. The oil was active against L. brasiliensis promastigotes; but not against the epimastigote form of T. cruzi. Cytotoxicity for mammalian cells was low at the active concentration capable of killing more than 70% of promastigote forms. The results revealed that the essential oil of R. echinus showed activity against L. brasiliensis; positioning itself as a promising agent for antileishmanial therapies.