Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection
Issued Date
2026-02-01
Resource Type
eISSN
21697574
Scopus ID
2-s2.0-105035499040
Journal Title
Plastic and Reconstructive Surgery Global Open
Volume
14
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Plastic and Reconstructive Surgery Global Open Vol.14 No.2 (2026) , e7509
Suggested Citation
Kim M., Suwanchinda A., Kim J.H., Hidajat I.J., Park S.Y., Yi K.H. Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection. Plastic and Reconstructive Surgery Global Open Vol.14 No.2 (2026) , e7509. doi:10.1097/GOX.0000000000007509 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116261
Title
Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection
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Corresponding Author(s)
Other Contributor(s)
Abstract
Background: – This study explores an alternative method of delivering polynucleotides (PNs) using a transdermal drug delivery device instead of traditional injection methods. These devices can deliver PNs in a noncontact manner and may offer several advantages over traditional injection techniques, including reduced pain and faster recovery time. Methods: – A clinical trial was conducted to compare the effectiveness of PN injections and transdermal drug delivery devices in 4 participants. Each participant received 3 treatments using the injection method on one side of the face and the transdermal drug delivery device on the other. The right hemiface was treated with cryogenic transdermal delivery (TargetCool), and the left hemiface was treated with manual intradermal injection. Outcomes were assessed through standardized photography and skin analysis, and participant satisfaction was examined using the Global Aesthetic Improvement Scale and visual analog scale. Results: – Treatment with the transdermal drug delivery device showed similar skin improvement to PN injection, with the advantage of less pain and a shorter recovery time. Skin density measurements using ultrasound showed that both methods were effective, but the transdermal drug delivery device provided slightly better skin density improvement in some cases. Conclusions: – Transdermal drug delivery devices are a safe and effective alternative to traditional PN injections, with similar skin improvement outcomes.