Divergent trajectories of antiviral memory after SARS-CoV-2 infection
Issued Date
2022-12-01
Resource Type
eISSN
20411723
Scopus ID
2-s2.0-85126422014
Pubmed ID
35273178
Journal Title
Nature Communications
Volume
13
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Communications Vol.13 No.1 (2022)
Suggested Citation
Tomic A., Skelly D.T., Ogbe A., O’Connor D., Pace M., Adland E., Alexander F., Ali M., Allott K., Azim Ansari M., Belij-Rammerstorfer S., Bibi S., Blackwell L., Brown A., Brown H., Cavell B., Clutterbuck E.A., de Silva T., Eyre D., Lumley S., Flaxman A., Grist J., Hackstein C.P., Halkerston R., Harding A.C., Hill J., James T., Jay C., Johnson S.A., Kronsteiner B., Lie Y., Linder A., Longet S., Marinou S., Matthews P.C., Mellors J., Petropoulos C., Rongkard P., Sedik C., Silva-Reyes L., Smith H., Stockdale L., Taylor S., Thomas S., Tipoe T., Turtle L., Vieira V.A., Wrin T., Stafford L., Abuelgasim H., Alhussni A., Arancibia-Cárcamo C.V., Borak M., Cutteridge J., Deeks A., Denly L., Dimitriadis S., Fassih S., Foord T., Fordwoh T., Holmes J., Horsington B., Kerneis S., Kim D., Lillie K., Morrow J., O’Donnell D., Ritter T.G., Simmons B., Taylor A., Thomas S.R., Warren Y., Watson A.J.R., Weeks E., Wilson R., Young R., Duncan C.J.A., Moore S.C., Payne R., Richter A., Rowland-Jones S., Mentzer A.J., Cassar M.P., Dong T., Fries A., Gilbert-Jaramillo J., Ho L.P., Knight J.C., Neubauer S., Peng Y., Petousi N., Raman B., Talbot N.P., Pollard A.J., Lambe T., Conlon C.P., Jeffery K., Travis S., Goulder P., Frater J. Divergent trajectories of antiviral memory after SARS-CoV-2 infection. Nature Communications Vol.13 No.1 (2022). doi:10.1038/s41467-022-28898-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83546
Title
Divergent trajectories of antiviral memory after SARS-CoV-2 infection
Author(s)
Tomic A.
Skelly D.T.
Ogbe A.
O’Connor D.
Pace M.
Adland E.
Alexander F.
Ali M.
Allott K.
Azim Ansari M.
Belij-Rammerstorfer S.
Bibi S.
Blackwell L.
Brown A.
Brown H.
Cavell B.
Clutterbuck E.A.
de Silva T.
Eyre D.
Lumley S.
Flaxman A.
Grist J.
Hackstein C.P.
Halkerston R.
Harding A.C.
Hill J.
James T.
Jay C.
Johnson S.A.
Kronsteiner B.
Lie Y.
Linder A.
Longet S.
Marinou S.
Matthews P.C.
Mellors J.
Petropoulos C.
Rongkard P.
Sedik C.
Silva-Reyes L.
Smith H.
Stockdale L.
Taylor S.
Thomas S.
Tipoe T.
Turtle L.
Vieira V.A.
Wrin T.
Stafford L.
Abuelgasim H.
Alhussni A.
Arancibia-Cárcamo C.V.
Borak M.
Cutteridge J.
Deeks A.
Denly L.
Dimitriadis S.
Fassih S.
Foord T.
Fordwoh T.
Holmes J.
Horsington B.
Kerneis S.
Kim D.
Lillie K.
Morrow J.
O’Donnell D.
Ritter T.G.
Simmons B.
Taylor A.
Thomas S.R.
Warren Y.
Watson A.J.R.
Weeks E.
Wilson R.
Young R.
Duncan C.J.A.
Moore S.C.
Payne R.
Richter A.
Rowland-Jones S.
Mentzer A.J.
Cassar M.P.
Dong T.
Fries A.
Gilbert-Jaramillo J.
Ho L.P.
Knight J.C.
Neubauer S.
Peng Y.
Petousi N.
Raman B.
Talbot N.P.
Pollard A.J.
Lambe T.
Conlon C.P.
Jeffery K.
Travis S.
Goulder P.
Frater J.
Skelly D.T.
Ogbe A.
O’Connor D.
Pace M.
Adland E.
Alexander F.
Ali M.
Allott K.
Azim Ansari M.
Belij-Rammerstorfer S.
Bibi S.
Blackwell L.
Brown A.
Brown H.
Cavell B.
Clutterbuck E.A.
de Silva T.
Eyre D.
Lumley S.
Flaxman A.
Grist J.
Hackstein C.P.
Halkerston R.
Harding A.C.
Hill J.
James T.
Jay C.
Johnson S.A.
Kronsteiner B.
Lie Y.
Linder A.
Longet S.
Marinou S.
Matthews P.C.
Mellors J.
Petropoulos C.
Rongkard P.
Sedik C.
Silva-Reyes L.
Smith H.
Stockdale L.
Taylor S.
Thomas S.
Tipoe T.
Turtle L.
Vieira V.A.
Wrin T.
Stafford L.
Abuelgasim H.
Alhussni A.
Arancibia-Cárcamo C.V.
Borak M.
Cutteridge J.
Deeks A.
Denly L.
Dimitriadis S.
Fassih S.
Foord T.
Fordwoh T.
Holmes J.
Horsington B.
Kerneis S.
Kim D.
Lillie K.
Morrow J.
O’Donnell D.
Ritter T.G.
Simmons B.
Taylor A.
Thomas S.R.
Warren Y.
Watson A.J.R.
Weeks E.
Wilson R.
Young R.
Duncan C.J.A.
Moore S.C.
Payne R.
Richter A.
Rowland-Jones S.
Mentzer A.J.
Cassar M.P.
Dong T.
Fries A.
Gilbert-Jaramillo J.
Ho L.P.
Knight J.C.
Neubauer S.
Peng Y.
Petousi N.
Raman B.
Talbot N.P.
Pollard A.J.
Lambe T.
Conlon C.P.
Jeffery K.
Travis S.
Goulder P.
Frater J.
Author's Affiliation
UK Health Security Agency
The Jenner Institute
NIHR Oxford Biomedical Research Centre
Oxford University Hospitals NHS Foundation Trust
Liverpool University Hospitals NHS Foundation Trust
The Wellcome Centre for Human Genetics
University of Oxford
University Hospitals Birmingham NHS Foundation Trust
Sheffield Teaching Hospitals NHS Foundation Trust
University of Liverpool
University of Birmingham
Monogram Biosciences
Sir William Dunn School of Pathology
Mahidol University
Nuffield Department of Medicine
The Sheffield Medical School
Newcastle University
University of Oxford Medical Sciences Division
The University of Sheffield
MRC Weatherall Institute of Molecular Medicine
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
The Jenner Institute
NIHR Oxford Biomedical Research Centre
Oxford University Hospitals NHS Foundation Trust
Liverpool University Hospitals NHS Foundation Trust
The Wellcome Centre for Human Genetics
University of Oxford
University Hospitals Birmingham NHS Foundation Trust
Sheffield Teaching Hospitals NHS Foundation Trust
University of Liverpool
University of Birmingham
Monogram Biosciences
Sir William Dunn School of Pathology
Mahidol University
Nuffield Department of Medicine
The Sheffield Medical School
Newcastle University
University of Oxford Medical Sciences Division
The University of Sheffield
MRC Weatherall Institute of Molecular Medicine
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Other Contributor(s)
Abstract
The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show a highly variable range of responses, some of which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B cell memory ELISpot) are stable. We use integrative analysis and a machine-learning approach (SIMON - Sequential Iterative Modeling OverNight) to explore this heterogeneity. We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also against variants B.1.1.7 (alpha) and B.1.351 (beta). These variable trajectories following early priming may define subsequent protection from severe disease from novel variants.