Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome
Issued Date
2023-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85165632623
Pubmed ID
37491408
Journal Title
Scientific Reports
Volume
13
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.13 No.1 (2023)
Suggested Citation
Hendrickx D.M., An R., Boeren S., Mutte S.K., Chatchatee P., Nowak-Wegrzyn A., Lange L., Benjaponpitak S., Chong K.W., Sangsupawanich P., van Ampting M.T.J., Oude Nijhuis M.M., Harthoorn L.F., Langford J.E., Knol J., Knipping K., Garssen J., Trendelenburg V., Pesek R., Davis C.M., Muraro A., Erlewyn-Lajeunesse M., Fox A.T., Michaelis L.J., Beyer K., Noimark L., Stiefel G., Schauer U., Hamelmann E., Peroni D., Boner A., Lambert J.M., Belzer C. Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome. Scientific Reports Vol.13 No.1 (2023). doi:10.1038/s41598-023-39260-w Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/88246
Title
Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome
Author(s)
Hendrickx D.M.
An R.
Boeren S.
Mutte S.K.
Chatchatee P.
Nowak-Wegrzyn A.
Lange L.
Benjaponpitak S.
Chong K.W.
Sangsupawanich P.
van Ampting M.T.J.
Oude Nijhuis M.M.
Harthoorn L.F.
Langford J.E.
Knol J.
Knipping K.
Garssen J.
Trendelenburg V.
Pesek R.
Davis C.M.
Muraro A.
Erlewyn-Lajeunesse M.
Fox A.T.
Michaelis L.J.
Beyer K.
Noimark L.
Stiefel G.
Schauer U.
Hamelmann E.
Peroni D.
Boner A.
Lambert J.M.
Belzer C.
An R.
Boeren S.
Mutte S.K.
Chatchatee P.
Nowak-Wegrzyn A.
Lange L.
Benjaponpitak S.
Chong K.W.
Sangsupawanich P.
van Ampting M.T.J.
Oude Nijhuis M.M.
Harthoorn L.F.
Langford J.E.
Knol J.
Knipping K.
Garssen J.
Trendelenburg V.
Pesek R.
Davis C.M.
Muraro A.
Erlewyn-Lajeunesse M.
Fox A.T.
Michaelis L.J.
Beyer K.
Noimark L.
Stiefel G.
Schauer U.
Hamelmann E.
Peroni D.
Boner A.
Lambert J.M.
Belzer C.
Author's Affiliation
Great North Children's Hospital
Nutricia Research, Netherlands
Utrechts Instituut voor Farmaceutische Wetenschappen
Azienda Ospedaliera Universitaria Integrata Verona
NYU Langone Health
St. Marien Hospital, Bonn
Azienda Ospedale Università Padova
Charité – Universitätsmedizin Berlin
Faculty of Medicine, Prince of Songkia University
Shanghai Jiao Tong University
Uniwersytet Warminsko-Mazurski w Olsztynie
Faculty of Medicine Ramathibodi Hospital, Mahidol University
KK Women's And Children's Hospital
The Royal London Hospital
Leicester Royal Infirmary
Guy's and St Thomas' NHS Foundation Trust
Ruhr-Universitat Bochum
Wageningen University & Research
Arkansas Children's Hospital
Faculty of Medicine, Chulalongkorn University
Baylor College of Medicine
University Hospital Southampton NHS Foundation Trust
Nutricia Research, Netherlands
Utrechts Instituut voor Farmaceutische Wetenschappen
Azienda Ospedaliera Universitaria Integrata Verona
NYU Langone Health
St. Marien Hospital, Bonn
Azienda Ospedale Università Padova
Charité – Universitätsmedizin Berlin
Faculty of Medicine, Prince of Songkia University
Shanghai Jiao Tong University
Uniwersytet Warminsko-Mazurski w Olsztynie
Faculty of Medicine Ramathibodi Hospital, Mahidol University
KK Women's And Children's Hospital
The Royal London Hospital
Leicester Royal Infirmary
Guy's and St Thomas' NHS Foundation Trust
Ruhr-Universitat Bochum
Wageningen University & Research
Arkansas Children's Hospital
Faculty of Medicine, Chulalongkorn University
Baylor College of Medicine
University Hospital Southampton NHS Foundation Trust
Other Contributor(s)
Abstract
Previous studies provide evidence for an association between modifications of the gut microbiota in early life and the development of food allergies. We studied the faecal microbiota composition (16S rRNA gene amplicon sequencing) and faecal microbiome functionality (metaproteomics) in a cohort of 40 infants diagnosed with cow’s milk allergy (CMA) when entering the study. Some of the infants showed outgrowth of CMA after 12 months, while others did not. Faecal microbiota composition of infants was analysed directly after CMA diagnosis (baseline) as well as 6 and 12 months after entering the study. The aim was to gain insight on gut microbiome parameters in relation to outgrowth of CMA. The results of this study show that microbiome differences related to outgrowth of CMA can be mainly identified at the taxonomic level of the 16S rRNA gene, and to a lesser extent at the protein-based microbial taxonomy and functional protein level. At the 16S rRNA gene level outgrowth of CMA is characterized by lower relative abundance of Lachnospiraceae at baseline and lower Bacteroidaceae at visit 12 months.