Optical Coherence Tomography Features for Identifying Posttreatment Complete Polypoidal Regression in Polypoidal Choroidal Vasculopathy
Issued Date
2022-09-15
Resource Type
eISSN
21620989
Scopus ID
2-s2.0-85139410715
Pubmed ID
36179334
Journal Title
Asia-Pacific Journal of Ophthalmology
Volume
11
Issue
5
Start Page
408
End Page
416
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asia-Pacific Journal of Ophthalmology Vol.11 No.5 (2022) , 408-416
Suggested Citation
Chaikitmongkol V., Chaovisitsaree T., Patikulsila D., Kunavisarut P., Phasukkijwatana N., Watanachai N., Choovuthayakorn J., Isipradit S., Boonyot P., Sangkaew A., Ingviya T., Bressler S.B., Bressler N.M. Optical Coherence Tomography Features for Identifying Posttreatment Complete Polypoidal Regression in Polypoidal Choroidal Vasculopathy. Asia-Pacific Journal of Ophthalmology Vol.11 No.5 (2022) , 408-416. 416. doi:10.1097/APO.0000000000000551 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85530
Title
Optical Coherence Tomography Features for Identifying Posttreatment Complete Polypoidal Regression in Polypoidal Choroidal Vasculopathy
Other Contributor(s)
Abstract
Purpose: To determine accuracy and relative risk (RR) of posttreatment optical coherence tomography (OCT) features in identifying complete or incomplete polypoidal regression in polypoidal choroidal vasculopathy (PCV). Design: Validity analysis. Methods: Treatment-naive PCV eyes undergoing OCT and indocyanine green angiography (ICGA) at baseline and posttreatment were included. Two graders confirmed diagnosis and identified posttreatment complete or incomplete regression on ICGA. Two other graders classified OCT characteristics of pigment epithelial detachment (PED) (polypoidal lesion) based on 5 prespecified features: "A," no PED; "B," PED with internal homogeneous reflectivity with predominant "BUN" (blended retinal pigment epithelium with underlying structure) sign; "C," PED with internal homogeneous reflectivity with minimal "BUN"; "D," heterogeneous PED; and "E," PED with hyporeflectivity. Results: Among 130 polypoidal lesions (65 pretreatment and 65 posttreatment) of 39 PCV eyes (39 patients; 54% female; mean age±SD: 64.6±8.2), all pretreatment lesions showed feature D on OCT. Posttreatment lesions with complete regression (31 lesions) showed OCT features A, B, C, D, and E in 32%, 45%, 13%, 10%, and 0%, respectively. Posttreatment lesions with incomplete regression (34 lesions) showed OCT features A, B, C, D, and E in 0%, 6%, 15%, 79%, and 0%, respectively. Presence of either feature A or B had highest accuracy (86%; 95% confidence interval: 75%-93%); 77% sensitivity; 94% specificity; RR 5.0 (3.5-7.1, P<0.001) for complete regression. Presence of feature D had highest accuracy (85%; 95% confidence interval: 74%-92%); 79% sensitivity; 90% specificity; RR 4.6 (3.0-6.9, P<0.001) for incomplete regression. Conclusions: Without ICGA, OCT features could provide high accuracy in identifying posttreatment complete or incomplete polypoidal regression in PCV.