Host kinase regulation of Plasmodium vivax dormant and replicating liver stages
Issued Date
2026-02-01
Resource Type
eISSN
19352735
Scopus ID
2-s2.0-105032159206
Pubmed ID
41739889
Journal Title
Plos Neglected Tropical Diseases
Volume
20
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Plos Neglected Tropical Diseases Vol.20 No.2 (2026) , e0014053
Suggested Citation
Glennon E.K.K., Wei L., Roobsoong W., Primavera V.I., van Zyl E.M., Tongogara T., Yee C.B., Sattabongkot J., Kaushansky A. Host kinase regulation of Plasmodium vivax dormant and replicating liver stages. Plos Neglected Tropical Diseases Vol.20 No.2 (2026) , e0014053. doi:10.1371/journal.pntd.0014053 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115717
Title
Host kinase regulation of Plasmodium vivax dormant and replicating liver stages
Corresponding Author(s)
Other Contributor(s)
Abstract
Upon transmission to the liver, Plasmodium vivax parasites form replicating schizonts, which progress to initiate blood-stage infection, or dormant hypnozoites that reactivate weeks to months after initial infection. P. vivax phenotypes in the field vary significantly, including the time to, and frequency of, relapse. Current evidence suggests that both parasite genetics and environmental factors underly this heterogeneity. Here, we applied an approach called kinase regression to evaluate the extent to which P. vivax liver-stage parasites are susceptible to changes in host kinase activity. We identified a role for a subset of host kinases in regulating the numbers of schizonts and hypnozoites, as well as schizont size, and characterized overlap as well as variability in host phosphosignaling dependencies between parasite forms across multiple patient isolates. Our data point to variability in host dependencies across P. vivax isolates, suggesting one possible origin of the heterogeneity observed in the field.