Evaluation of 14-day Concentration-time Curves of Vitamin D<inf>3</inf> and 25-Hydroxyvitamin D<inf>3</inf> in Healthy Adults With Varying Body Mass Index
Issued Date
2022-10-01
Resource Type
ISSN
02507005
eISSN
17917530
Scopus ID
2-s2.0-85139128620
Pubmed ID
36191982
Journal Title
Anticancer Research
Volume
42
Issue
10
Start Page
5095
End Page
5100
Rights Holder(s)
SCOPUS
Bibliographic Citation
Anticancer Research Vol.42 No.10 (2022) , 5095-5100
Suggested Citation
Charoenngam N., Mueller P.M., Holick M.F. Evaluation of 14-day Concentration-time Curves of Vitamin D<inf>3</inf> and 25-Hydroxyvitamin D<inf>3</inf> in Healthy Adults With Varying Body Mass Index. Anticancer Research Vol.42 No.10 (2022) , 5095-5100. 5100. doi:10.21873/anticanres.16019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85488
Title
Evaluation of 14-day Concentration-time Curves of Vitamin D<inf>3</inf> and 25-Hydroxyvitamin D<inf>3</inf> in Healthy Adults With Varying Body Mass Index
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Background/Aim: To analyze the concentration-time curves of single-dose oral 25(OH)D3 in comparison with vitamin D3 in healthy adults. Patients and Methods: The pharmacokinetics observed over two weeks after orally administering single 900 μg doses of vitamin D3 and 25(OH)D3 to six otherwise healthy vitamin D insufficient/deficient adults participating in a broader randomized, double-blind, crossover, single center trial was analyzed. The study protocol was approved by the institutional review board (H-37167). Results: Individual concentration-time curves revealed that vitamin D3 took longer than 25(OH)D3 to reach its maximal concentration after ingestion in five participants. After 25(OH)D3 ingestion, 25(OH)D3 reached its maximal concentration, dropped rapidly, and plateaued before starting to decrease slowly. There were observable inter-individual variations in the bioavailability of vitamin D3 and 25(OH)D3 and the pattern of changes in 25(OH)D3 concentration after their ingestion. Conclusion: Pharmacokinetics of 25(OH)D3 in comparison with vitamin D3 was illustrated and described in this study.