Mitochondrial dysfunction from malathion and chlorpyrifos exposure is associated with degeneration of GABAergic neurons in Caenorhabditis elegans
Issued Date
2022-11-01
Resource Type
ISSN
13826689
eISSN
18727077
Scopus ID
2-s2.0-85140319178
Pubmed ID
36252730
Journal Title
Environmental Toxicology and Pharmacology
Volume
96
Rights Holder(s)
SCOPUS
Bibliographic Citation
Environmental Toxicology and Pharmacology Vol.96 (2022)
Suggested Citation
Thosapornvichai T., Huangteerakul C., Jensen A.N., Jensen L.T. Mitochondrial dysfunction from malathion and chlorpyrifos exposure is associated with degeneration of GABAergic neurons in Caenorhabditis elegans. Environmental Toxicology and Pharmacology Vol.96 (2022). doi:10.1016/j.etap.2022.104000 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84661
Title
Mitochondrial dysfunction from malathion and chlorpyrifos exposure is associated with degeneration of GABAergic neurons in Caenorhabditis elegans
Author's Affiliation
Other Contributor(s)
Abstract
Toxicity resulting from off-target effects, beyond acetylcholine esterase inhibition, for the commonly used organophosphate (OP) insecticides chlorpyrifos (CPS) and malathion (MA) was investigated using Saccharomyces cerevisiae and Caenorhabditis elegans model systems. Mitochondrial damage and dysfunction were observed in yeast following exposure to CPS and MA, suggesting this organelle is a major target. In the C. elegans model, the mitochondrial unfolded protein response pathway showed the most robust induction from CPS and MA treatment among stress responses examined. GABAergic neurodegeneration was observed with CPS and MA exposure. Impaired movement observed in C. elegans exposed to CPS and MA may be the result of motor neuron damage. Our analysis suggests that stress from CPS and MA results in mitochondrial dysfunction, with GABAergic neurons sensitized to these effects. These findings may aid in the understanding of toxicity from CPS and MA from high concentration exposure leading to insecticide poisoning.