A high-protein peptide-based enteral formula improves diarrhea in tube-fed patients: A prospective multicenter study
Issued Date
2022-01-01
Resource Type
ISSN
02601060
eISSN
2047945X
Scopus ID
2-s2.0-85143639867
Journal Title
Nutrition and Health
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nutrition and Health (2022)
Suggested Citation
Rattanachaiwong S., Siritientong T., Pisprasert V., Hongsprabhas P., Deawtrakulchai P., Williams S., Suebsoh N., Samuksaman S., Bunsut P., Pramyothin P., Khumkhana N., Tipsung P., Vattanapongpisan M., Promsin P. A high-protein peptide-based enteral formula improves diarrhea in tube-fed patients: A prospective multicenter study. Nutrition and Health (2022). doi:10.1177/02601060221136918 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86245
Title
A high-protein peptide-based enteral formula improves diarrhea in tube-fed patients: A prospective multicenter study
Author's Affiliation
Other Contributor(s)
Abstract
Background: Diarrhea is a common problem in tube-fed patients. The relevant guidelines suggest using a peptide-based enteral formula in patients with diarrhea; however, sufficient evidence to support this recommendation is currently lacking. Aim: This study aimed to evaluate the effects of a high-protein peptide-based formula on gastrointestinal intolerance, mainly focusing on diarrhea symptoms in patients who were intolerant to polymeric formula feeding. Methods: This prospective, single-arm, open-label, multicenter study was conducted from March 2021 to March 2022 at two tertiary-care hospitals. Patients who presented with diarrhea during tube feeding with polymeric formula were assigned to receive a high-protein peptide-based formula for ≤7 days. Stool weight and frequency were monitored at baseline, on day 3, and on day 7 (or end of the study) as the primary outcomes. Results: Twenty-eight tube-fed patients with diarrhea were recruited. After switching their feeding formula from polymeric to peptide based, significant improvements in stool frequency and stool weight were observed on day 3 and day 7 compared with the baseline (median [IQR] stool frequency: 5 (2), 2.5 (3.5), and 3 (3) times/day, respectively, p <0.001; median stool weight: 500 (370), 170 (285), and 275 (385) gram/day, respectively, p = 0.015). Stool consistency was assessed using the Bristol Stool Score and showed significant improvement with time. No serious adverse events were reported. Conclusion: A high-protein peptide-based enteral formula was effective in reducing stool weight and frequency in patients who experienced diarrhea during tube feeding with a polymeric formula. Trial registration: TCTR20210302006