Hypoxic Pulmonary Vasoconstriction: Relevance to Anesthetic Practice
5
Issued Date
2025-03-01
Resource Type
ISSN
01252208
Scopus ID
2-s2.0-105007280930
Journal Title
Journal of the Medical Association of Thailand
Volume
108
Issue
3
Start Page
250
End Page
256
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand Vol.108 No.3 (2025) , 250-256
Suggested Citation
Sombood P., Jainwitayakit S., Aekta A., Sritanapongsa I., Vichitvejpaisal P., Vichitvejpaisal P. Hypoxic Pulmonary Vasoconstriction: Relevance to Anesthetic Practice. Journal of the Medical Association of Thailand Vol.108 No.3 (2025) , 250-256. 256. doi:10.35755/jmedassocthai.2025.3.250-256-00420 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110644
Title
Hypoxic Pulmonary Vasoconstriction: Relevance to Anesthetic Practice
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Hypoxic pulmonary vasoconstriction (HPV) is a physiological response of the pulmonary vasculature to hypoxia, resulting in vasoconstriction in poorly ventilated areas of the lungs and redirecting blood flow to well-ventilated areas. Understanding the significance of HPV is crucial in the context of anesthesia for perioperative management. The complex interplay between HPV, oxygen tension, CO<inf>2</inf> levels, and pH is essential for anesthesiologists to tailor ventilation strategies and optimize patient outcomes, particularly in individuals with pre-existing pulmonary hypertension (PH) or acute respiratory distress syndrome. This reflex plays a critical role in maintaining adequate oxygenation during anesthesia by preserving ventilation-perfusion matching and optimizing oxygen delivery to the body through redirection of blood flow to well-ventilated lung regions. Pharmacological manipulation of HPV using drugs that enhance or inhibit its response can be utilized in specific clinical scenarios, such as in patients with PH or during thoracic surgeries, to optimize hemodynamics and improve patient outcomes. Future research in anesthesia aims to elucidate the molecular and cellular mechanisms of HPV, investigate genetic and epigenetic factors that influence it, develop novel pharmacological agents, conduct large-scale clinical trials and outcome studies, and foster multidisciplinary collaborations.