The sex-specific metabolic signature of C57BL/6NRj mice during aging
Issued Date
2022-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85143422719
Pubmed ID
36473898
Journal Title
Scientific Reports
Volume
12
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.12 No.1 (2022)
Suggested Citation
Bresilla D., Habisch H., Pritišanac I., Zarse K., Parichatikanond W., Ristow M., Madl T., Madreiter-Sokolowski C.T. The sex-specific metabolic signature of C57BL/6NRj mice during aging. Scientific Reports Vol.12 No.1 (2022). doi:10.1038/s41598-022-25396-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87540
Title
The sex-specific metabolic signature of C57BL/6NRj mice during aging
Author's Affiliation
Other Contributor(s)
Abstract
Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj mice are especially suitable to study cellular alterations in metabolism. We applied Nuclear Magnetic resonance spectroscopy to analyze five different tissues of this mouse strain during aging and included female and male mice aged 3, 6, 12, and 24 months. Metabolite signatures allowed separation between the age groups in all tissues, and we identified the most prominently changing metabolites in female and male tissues. A refined analysis of individual metabolite levels during aging revealed an early onset of age-related changes at 6 months, sex-specific differences in the liver, and a biphasic pattern for various metabolites in the brain, heart, liver, and lung. In contrast, a linear decrease of amino acids was apparent in muscle tissues. Based on these results, we assume that age-related metabolic alterations happen at a comparably early aging state and are potentially associated with a metabolic switch. Moreover, identified differences between female and male tissues stress the importance of distinguishing between sexes when studying age-related changes and developing new treatment approaches. Besides, metabolomic features seem to be highly dependent on the genetic background of mouse strains.