Primary Oral Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature
Issued Date
2024-02-23
Resource Type
eISSN
19360568
Scopus ID
2-s2.0-85185860716
Pubmed ID
38393494
Journal Title
Head and neck pathology
Volume
18
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Head and neck pathology Vol.18 No.1 (2024) , 13
Suggested Citation
Sripodok P., Kouketsu A., Kuroda K., Miyashita H., Sugiura T., Kumamoto H. Primary Oral Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature. Head and neck pathology Vol.18 No.1 (2024) , 13. doi:10.1007/s12105-024-01613-w Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97427
Title
Primary Oral Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature
Corresponding Author(s)
Other Contributor(s)
Abstract
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare tumors recently characterized by the presence of both neuroendocrine and non-neuroendocrine components within the same tumor tissue. Although MiNEN found their place in the WHO classification for various organs, this composite tumor in the head and neck region remains exceptionally rare. We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocrine carcinoma (NEC) and the patient underwent partial mandibulectomy. The resected specimen showed two distinct components of NEC and squamous cell carcinoma (SCC) with the confirmation of immunohistochemical markers. There has been no sign of recurrence nor metastasis 6 years after the surgery. In addition, we have conducted a review of published cases with potential relevance to this entity, resulting in five cases. The diverse terminology reinforces the need for a standardized classification system of oral/head and neck MiNENs.