Targeting MYC at the intersection between cancer metabolism and oncoimmunology
Issued Date
2024-01-01
Resource Type
eISSN
16643224
Scopus ID
2-s2.0-85185502251
Journal Title
Frontiers in Immunology
Volume
15
Rights Holder(s)
SCOPUS
Bibliographic Citation
Frontiers in Immunology Vol.15 (2024)
Suggested Citation
Venkatraman S., Balasubramanian B., Thuwajit C., Meller J., Tohtong R., Chutipongtanate S. Targeting MYC at the intersection between cancer metabolism and oncoimmunology. Frontiers in Immunology Vol.15 (2024). doi:10.3389/fimmu.2024.1324045 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97398
Title
Targeting MYC at the intersection between cancer metabolism and oncoimmunology
Corresponding Author(s)
Other Contributor(s)
Abstract
MYC activation is a known hallmark of cancer as it governs the gene targets involved in various facets of cancer progression. Of interest, MYC governs oncometabolism through the interactions with its partners and cofactors, as well as cancer immunity via its gene targets. Recent investigations have taken interest in characterizing these interactions through multi-Omic approaches, to better understand the vastness of the MYC network. Of the several gene targets of MYC involved in either oncometabolism or oncoimmunology, few of them overlap in function. Prominent interactions have been observed with MYC and HIF-1α, in promoting glucose and glutamine metabolism and activation of antigen presentation on regulatory T cells, and its subsequent metabolic reprogramming. This review explores existing knowledge of the role of MYC in oncometabolism and oncoimmunology. It also unravels how MYC governs transcription and influences cellular metabolism to facilitate the induction of pro- or anti-tumoral immunity. Moreover, considering the significant roles MYC holds in cancer development, the present study discusses effective direct or indirect therapeutic strategies to combat MYC-driven cancer progression.
