The Association of Cholesterol Transport ABCG 1 Polymorphism Towards the Susceptibility of Metabolic Syndrome Risk Factorin Thai Adolescents
Issued Date
2022-08-01
Resource Type
ISSN
2347467X
eISSN
23220007
Scopus ID
2-s2.0-85137343851
Journal Title
Current Research in Nutrition and Food Science
Volume
10
Issue
2
Start Page
512
End Page
520
Rights Holder(s)
SCOPUS
Bibliographic Citation
Current Research in Nutrition and Food Science Vol.10 No.2 (2022) , 512-520
Suggested Citation
Sidabutar L.M.G.B., Pongcharoen T., Suttisansanee U., On-Nom N., Luealai P., Khemthong C., Chupeerach C. The Association of Cholesterol Transport ABCG 1 Polymorphism Towards the Susceptibility of Metabolic Syndrome Risk Factorin Thai Adolescents. Current Research in Nutrition and Food Science Vol.10 No.2 (2022) , 512-520. 520. doi:10.12944/CRNFSJ.10.2.8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85645
Title
The Association of Cholesterol Transport ABCG 1 Polymorphism Towards the Susceptibility of Metabolic Syndrome Risk Factorin Thai Adolescents
Author's Affiliation
Other Contributor(s)
Abstract
Asian countries now suffers from a double burden issue that involves metabolic syndrome (Met S) even in the adolescent age. Many factors have been considered to explain this situation including genetic variation contribution to the susceptibility of said metabolic syndrome. ATP-Binding Cassette G1 (ABCG1) is known in its role in cholesterol efflux that is strongly related in lipid accumulation and insulin performance. In addition to this gene modulation work in reverse cholesterol transport that is also connected with the occurrence of metabolic syndrome. However, the effect of polymorphism in rs 1044317 remains unclear. A total of 434 subjects in adolescent age were genotyped for ABCG1 rs1044317 by restricted fragmented length polymorphism polymerase chain reaction method. All the anthropometric and laboratory date was extracted by an approved protocol. The correlation of each variables was detected using SPSS ver.21. Frequencies of alleles and genotypes of the ABCG1 polymorphism were similar in both sexes. A significant correlation detected between adjusted males’ group with an increased level of interleukin-6 in wide genotype and an increased fasting blood sugar level in adjusted females’ group in variant genotype. The existence of rs1044317 ABCG1 SNP affected the susceptibility of specific criteria of Met S in Thai adolescence population. Additionally, there is a gender difference in the incidence of Met S, indicating a possible gene–gender interaction of the ABCG1 polymorphism in Met S among Thai adolescents.
