The Khamkhains, Neurotrophic Drimane-Type Sesquiterpenoids Derived from a Polyporaceous Basidiomycete Originating from Thailand
Issued Date
2025-07-25
Resource Type
eISSN
15206025
Scopus ID
2-s2.0-105012416897
Pubmed ID
40669013
Journal Title
Journal of Natural Products
Volume
88
Issue
7
Start Page
1840
End Page
1846
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Natural Products Vol.88 No.7 (2025) , 1840-1846
Suggested Citation
Paomephan P., Hassan K., Kirchenwitz M., Pfütze S., Surup F., Císařová I., Boonchird C., Stadler M. The Khamkhains, Neurotrophic Drimane-Type Sesquiterpenoids Derived from a Polyporaceous Basidiomycete Originating from Thailand. Journal of Natural Products Vol.88 No.7 (2025) , 1840-1846. 1846. doi:10.1021/acs.jnatprod.5c00669 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111610
Title
The Khamkhains, Neurotrophic Drimane-Type Sesquiterpenoids Derived from a Polyporaceous Basidiomycete Originating from Thailand
Corresponding Author(s)
Other Contributor(s)
Abstract
Eight unprecedented terpenoids were isolated from submerged cultures of a polyporoid basidiomycete originating from Thailand (which had been referred to as "Cerrena sp." in a previous publication) by preparative chromatography. Their chemical structures were elucidated by extensive two-dimensional nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry. One of the compounds was crystallized, and its absolute configuration was established by X-ray crystallography. Among the isolated metabolites were several members of the rare nitrogen-containing drimane type and one dimeric drimane, which consists of a nitrogen-containing monomer and a regular monomer. The latter compound represents a hitherto unknown type of terpenoid natural product. The metabolites were subjected to a biological characterization, and some of them showed significant neurotrophic effects. Notably, several of the compounds significantly enhanced the outgrowth of neurites in PC12 cells when treated with 5 ng/mL nerve growth factor. On the other hand, they were devoid of significant cytotoxic and antimicrobial effects.