TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.

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dc.contributor.authorRakkreat Wikiniyadhanee
dc.contributor.authorTassanee Lerksuthirat
dc.contributor.authorWasana Stitchantrakul
dc.contributor.authorSermsiri Chitphuk
dc.contributor.authorThanyachai Sura
dc.contributor.authorDonniphat Dejsuphong
dc.date.accessioned2024-03-28T02:46:02Z
dc.date.available2024-03-28T02:46:02Z
dc.date.created2023-03-16
dc.date.issued2020
dc.descriptionSYNTRAIN CONFERENCE Genomic Instability in Cancer From tumour evolution to novel cures (online event).Organized by the SYNTRAIN Consortuim and the University of Patras, Greece. October 20-22, 2020
dc.description.abstractTripartite motif-containing protein 29 (TRIM29) is involved in DNA double-strand break (DSB) repair. However, the specific roles of TRIM29 in DNA repair are not clearly understood. To investigate the involvement of TRIM29 in DNA DSB repair, we disrupted TRIM29 in DT40 cells by gene targeting with homologous recombination (HR). Disrupting three alleles of TRIM29 not only decreased the recruitment of 53BP1, but also subsequently increased the recruitment of RAD51 to DNA DSBs in response to DNA DSBs in vertebrate cells.
dc.description.sponsorshipFaculty of Graduate Studies, Mahidol University Academic Year 2018 and Thailand Research Fund (TRF5880149)
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/97772
dc.language.isoeng
dc.rightsผลงานนี้สงวนสิทธิ์โดยมหาวิทยาลัยมหิดล ห้ามทำซ้ำ คัดลอก หรือนำไปเผยแพร่ตัดต่อโดยมิได้รับอนุญาตเป็นลายลักษณ์อักษร
dc.rights.holderSYNTRAIN Consortuim and the University of Patras
dc.subjectDT40
dc.subjectTRIM29
dc.subjectDNA damage
dc.subjectDNA repair
dc.subjectDNA double-strand breaks
dc.titleTRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
dc.typePoster Presentation
dcterms.accessRightsopen access
oairecerif.author.affiliationMahidol University. Faculty of Medicine, Ramathibodi Hospital. Section for Translational Medicine
oairecerif.author.affiliationMahidol University. Faculty of Medicine, Ramathibodi Hospital. Research Center
oairecerif.author.affiliationMahidol University. Faculty of Medicine, Ramathibodi Hospital. Department of Internal Medicine
oairecerif.event.nameSYNTRAIN CONFERENCE Genomic Instability in Cancer From tumour evolution to novel cures (online event)
oairecerif.event.placeGreece

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