The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study
Issued Date
2024-01-01
Resource Type
eISSN
20770383
Scopus ID
2-s2.0-85183358710
Journal Title
Journal of Clinical Medicine
Volume
13
Issue
2
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SCOPUS
Bibliographic Citation
Journal of Clinical Medicine Vol.13 No.2 (2024)
Suggested Citation
Santamonkunrot P., Samutchinda S., Niransuk P., Satirapod C., Sukprasert M. The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study. Journal of Clinical Medicine Vol.13 No.2 (2024). doi:10.3390/jcm13020626 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/95713
Title
The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study
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Abstract
Embryo morphology and morphokinetics have been studied for their association with euploid embryos. However, the results are controversial, especially in the advanced-aged women group, when the risk of aneuploidy increases significantly. This prospective cohort study evaluated the association between embryo development between day-3 cleavage and day-5 blastocyst stages and euploidy rates, determined using preimplantation genetic testing for aneuploidy (PGT-A). Embryos from women aged 35 years and above who underwent intracytoplasmic sperm injections and PGT-A were studied. Day-3 cleavage-stage embryos were evaluated for their cell number, and day-5 blastocyst-stage embryos were evaluated for their morphological grade. Embryo development from day 3 to day 5 was categorized as either good or poor development and evaluated for its association with the PGT-A results. We evaluated 325 embryos from 101 infertile couples. It was found that 55.17% of blastocysts with good development and 29.83% with poor development were euploid. A significant association was found between embryo development and euploidy rates in advanced-aged women (p < 0.001). Also, there were significantly higher rates of euploid embryos with good blastocyst morphological grades, especially blastocyst expansion grades and trophectoderm grades. In conclusion, embryo morphokinetics shows promising results in predicting euploidy in advanced female age.