Association between Drug Therapy and Risk of Incident Frailty: A Systematic Review
Issued Date
2024-09-01
Resource Type
ISSN
25084798
eISSN
25084909
Scopus ID
2-s2.0-85206260418
Journal Title
Annals of Geriatric Medicine and Research
Volume
28
Issue
3
Start Page
247
End Page
256
Rights Holder(s)
SCOPUS
Bibliographic Citation
Annals of Geriatric Medicine and Research Vol.28 No.3 (2024) , 247-256
Suggested Citation
Thanapluetiwong S., Chattaris T., Shi S.M., Park C.M., Sison S.D.M., Kim D.H. Association between Drug Therapy and Risk of Incident Frailty: A Systematic Review. Annals of Geriatric Medicine and Research Vol.28 No.3 (2024) , 247-256. 256. doi:10.4235/agmr.24.0034 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/101682
Title
Association between Drug Therapy and Risk of Incident Frailty: A Systematic Review
Corresponding Author(s)
Other Contributor(s)
Abstract
Medication is a potential factor influencing frailty. However, the relationship between pharmaceutical treatments and frailty remains unclear. Therefore, we conducted the present systematic review to summarize the association between drug therapy and the risk of incident frailty in older adults. We systematically searched the MEDLINE electronic database for articles indexed between January 1, 2000, and December 31, 2021, for randomized controlled trials (RCTs) and cohort studies reporting frailty changes associated with drug therapy. A total of six RCTs and 13 cohort studies involving 211,948 participants were identified, and their treatments were categorized into six medication classes: analgesics, cardiometabolic medication, chemotherapy, central nervous system (CNS)-active medication, hormonal therapy, and nutritional supplements. While the analysis revealed that only CNS-active medications were associated with an elevated risk of frailty, other medication classes also affected frailty; however, this is not conclusively attributable to a class-wide effect.