Mitochondrial DNA content as a diagnostic marker for antituberculosis drug-induced liver injury
Issued Date
2022-09-01
Resource Type
ISSN
12019712
eISSN
18783511
Scopus ID
2-s2.0-85136141465
Pubmed ID
35931370
Journal Title
International Journal of Infectious Diseases
Volume
122
Start Page
1034
End Page
1040
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases Vol.122 (2022) , 1034-1040
Suggested Citation
Udomsinprasert W., Jittikoon J., Chaikledkaew U., Saengsiwaritt W., Chanhom N., Suvichapanich S., Wattanapokayakit S., Mahasirimongkol S., Chantratita W. Mitochondrial DNA content as a diagnostic marker for antituberculosis drug-induced liver injury. International Journal of Infectious Diseases Vol.122 (2022) , 1034-1040. 1040. doi:10.1016/j.ijid.2022.07.071 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85583
Title
Mitochondrial DNA content as a diagnostic marker for antituberculosis drug-induced liver injury
Author's Affiliation
Other Contributor(s)
Abstract
Objectives: This study aimed to investigate whether mitochondrial DNA (mtDNA) content, an index of mitochondrial dysfunction, was associated with clinical parameters indicating anti-tuberculosis (TB) drug-induced liver injury (ATDILI) in TB patients and could emerge as an ATDILI biomarker. Methods: Leukocyte mtDNA content in 102 TB patients (49 ATDILI cases and 53 non-ATDILI cases) and 100 age-matched healthy controls was measured using real-time polymerase chain reaction. Results: Compared with healthy controls, both TB patients with and without ATDILI had significantly decreased mtDNA content. Compared with the patients without ATDILI, mtDNA content was significantly increased in those with ATDILI. Higher mtDNA content was observed to be independently associated with increased susceptibility to ATDILI. Increased mtDNA content measured within 1-7 days of treatment was independently associated with elevated levels of serum aminotransferases assessed within 8-60 days of treatment. After initiating treatment within 1-7 days, mtDNA content was detected to be more sensitive and selective for differentiating TB patients with ATDILI from those without ATDILI than serum aminotransferases. Kaplan-Meier analysis revealed a significant correlation between elevated mtDNA content and increased rate of ATDILI occurrence in TB patients, attested by Cox regression analysis, adjusting for confounders. Conclusion: Changes in leukocyte mtDNA content would reflect ATDILI progression and could be used as a potential stratification tool for identifying TB patients at risk of ATDILI.