Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021
Issued Date
2024-01-01
Resource Type
eISSN
29937175
Scopus ID
2-s2.0-85212500525
Journal Title
Alcohol, Clinical and Experimental Research
Rights Holder(s)
SCOPUS
Bibliographic Citation
Alcohol, Clinical and Experimental Research (2024)
Suggested Citation
Danpanichkul P., Duangsonk K., Tham E.K.J., Tothanarungroj P., Auttapracha T., Prasitsumrit V., Sim B., Tung D., Barba R., Wong R.J., Leggio L., Yang J.D., Chen V.L., Noureddin M., Díaz L.A., Arab J.P., Wijarnpreecha K., Liangpunsakul S. Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021. Alcohol, Clinical and Experimental Research (2024). doi:10.1111/acer.15516 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102531
Title
Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021
Author's Affiliation
Siriraj Hospital
National University Health System
Richard L. Roudebush VAMC
Escuela de Medicina
TTUHSC School of Medicine
University of Michigan Medical School
Stanford University School of Medicine
Faculty of Medicine, Chiang Mai University
University of California, San Diego
VA Palo Alto Health Care System
NUS Yong Loo Lin School of Medicine
Indiana University School of Medicine
National Institute on Drug Abuse (NIDA)
Cedars-Sinai Medical Center
Houston Methodist Hospital
VCU School of Medicine
University of Arizona College of Medicine – Phoenix
Banner - University Medical Center Phoenix
Observatorio Multicéntrico de Enfermedades Gastrointestinales (OMEGA)
National University Health System
Richard L. Roudebush VAMC
Escuela de Medicina
TTUHSC School of Medicine
University of Michigan Medical School
Stanford University School of Medicine
Faculty of Medicine, Chiang Mai University
University of California, San Diego
VA Palo Alto Health Care System
NUS Yong Loo Lin School of Medicine
Indiana University School of Medicine
National Institute on Drug Abuse (NIDA)
Cedars-Sinai Medical Center
Houston Methodist Hospital
VCU School of Medicine
University of Arizona College of Medicine – Phoenix
Banner - University Medical Center Phoenix
Observatorio Multicéntrico de Enfermedades Gastrointestinales (OMEGA)
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: To investigate the trends in alcohol-associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US). Methods: We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age-standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (>70 years) in the United States. The findings were contrasted with global estimates and categorized by sex and state. Results: In 2021, there were approximately 512,340 cases of AUD, 56,990 cases of ALD, and 4490 cases of primary liver cancer from alcohol among older adults in the United States. In contrast to declining ASRs of prevalence and mortality in the global burden, these parameters were increased in older adults in the United States. From 2000 to 2021, prevalence from AUD (APC: 0.54%, 95% CI 0.43% to 0.65%), ALD (APC + 0.54%, 95% CI 0.22% to 0.86%), and primary liver cancer from alcohol (APC 2.93%, 95% CI 2.76% to 3.11%) increased. Forty states in the United States exhibited a rise in the prevalence rates of ALD in older adults. Conclusion: Our findings highlighted the increased prevalence and mortality of AUD, ALD, and primary liver cancer from alcohol among older adults in the United Sates, contrasting with the decline in global trends. Public health strategies on ALD, AUD, and primary liver cancer from alcohol, which targets older adults, are urgently needed.