Effects of butylated hydroxyanisole on initiation of hepatopancreatic carcinogenesis in opisthorchis viverrini infected female syrian golden hamsters
1
Issued Date
1990
Copyright Date
1990
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xi, 96 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Pathobiology))--Mahidol University, 1990
Suggested Citation
Nichada Chawajaroenpan Effects of butylated hydroxyanisole on initiation of hepatopancreatic carcinogenesis in opisthorchis viverrini infected female syrian golden hamsters. Thesis (M.Sc. (Pathobiology))--Mahidol University, 1990. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103332
Title
Effects of butylated hydroxyanisole on initiation of hepatopancreatic carcinogenesis in opisthorchis viverrini infected female syrian golden hamsters
Alternative Title(s)
ผลของสารบิวติเรสเดดไฮดรอทซีอะนิโซลที่มีต่อระยะเริ่มแรกของการเกิดมะเร็งที่ตับและตับอ่อน ในหนูทดลองแฮมสเตอร์ตัวเมียที่มีการติดเชื้อพยาธิใบไม้ในตับ
Author(s)
Advisor(s)
Abstract
The effects of concomitant Opisthorchis viverrini infection and butylated hydroxyanisole administration on dihydroxy-di-n-propylnitrosamine (DHPN) initiation of pancreatic and liver neoplasia were investigated in female Syrian golden hamsters. Two weeks subsequent to infection with 80 metacercariae by stomach gavage administration of BHA (1%) in the diet was commenced. Four 600 mg.kg body weight doses of DHPN were then administered by incorporation at week 6 one day after the last injection of carcinogen revealed parasite infection to be associated with inflammatory and proliferative changes in the livers of infected hamsters. Carcinogen treatment caused toxicity and increased in labelling indices of hepatocytes bile duct and gallbladder epithelial cells. These lesions were reduced by the BHA treatment which was also associated with and increase in total glutathione-s-transferase activity. Comparison of preneoplastic and neoplastic lesions development at week 26 revealed significant reduction in the yields of clear cell hepatocyte foci cholangiofibrotic areas and cholangiocellular carcinomas as well as carcinogen-induced pancreatic cysts and dysplastic lesions in BHA-treated animals. The antioxidant BHA thus exerted an inhibitory influence on initiation of pancreato-hepatic carcinogenesis in the hamster Opisthorchis Viverrini model suggesting a possible protective role for this type of agent in the human situation.
Description
Pathobiology (Mahidol University 1990)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Pathobiology
Degree Grantor(s)
Mahidol University