Rearrangement of the bacterial genome during infection with burkholderia pseudomallei, the cause of melioidosis

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dc.contributor.authorMaharjan, Binaen_US
dc.contributor.authorVanaporn Wuthiekanunen_US
dc.contributor.authorวรรณพร วุฒิเอกอนันต์en_US
dc.contributor.authorWirongrong Chierakulen_US
dc.contributor.authorวิรงค์รอง เจียรกุลen_US
dc.contributor.authorMongkol Vesaratchavesten_US
dc.contributor.authorมงคล เวสารัชเวศย์en_US
dc.contributor.authorNarisara Chantratitaen_US
dc.contributor.authorนริศรา จันทราทิตย์en_US
dc.contributor.authorWipada Chaowagulen_US
dc.contributor.authorWhite, Nicholas Jen_US
dc.contributor.authorDay, Nicholas PJen_US
dc.contributor.authorPeacock, Sharon Jen_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. The Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programmeen_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicineen_US
dc.date.accessioned2016-03-15T07:07:53Z
dc.date.accessioned2021-09-02T05:56:54Z
dc.date.available2016-03-15T07:07:53Z
dc.date.available2021-09-02T05:56:54Z
dc.date.created2016-03-15
dc.date.issued2004
dc.descriptionJoint International Tropical Medicine Meeting 2004: Ambassador Hotel, Thailand 29 November-1 December 2004: abstract. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2004. p.262.en
dc.description.abstractRecurrent melioidosis occurs in more than 10% of patients in north eastern Thailand, despite an adequate course of antibiotic treatment. Affected patients have a mortality rate equivalecnt ot the first episode, indicating the importance of understanding this process. The aim of this study was to examine the hypothesis that isolates associated with relapse undergo genomic rearrangement as part of a process of survival adaptation and persistence. Seventy patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani with recurrent meliodosis were identified from our database. Isolates from the primary and recurrent episodes were obtained from a -80°C freezer library, and examined in parallel by pulsed field gel electrophoresis. Any pair in which one or more bands were different was considered to represent either a new infecting isolate or genomic rearrangement. Multilocus sequence typing was used in these cases to resolve between the twoen_US
dc.identifier.urihttps://hdl.handle.net/20.500.14594/63415
dc.language.isoengen_US
dc.rightsMahidol Universityen_US
dc.subjectBacterialen_US
dc.subjectMelioidosisen_US
dc.titleRearrangement of the bacterial genome during infection with burkholderia pseudomallei, the cause of melioidosisen_US
dc.typeProceeding Posteren_US
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