Antimicrobial-resistant Bacteroides fragilis in Thailand and their inhibitory effect in vitro on the growth of Clostridioides difficile
Issued Date
2022-02-01
Resource Type
ISSN
10759964
eISSN
10958274
Scopus ID
2-s2.0-85122124021
Pubmed ID
34973432
Journal Title
Anaerobe
Volume
73
Rights Holder(s)
SCOPUS
Bibliographic Citation
Anaerobe Vol.73 (2022)
Suggested Citation
Imwattana K., Kiratisin P., Riley T.V. Antimicrobial-resistant Bacteroides fragilis in Thailand and their inhibitory effect in vitro on the growth of Clostridioides difficile. Anaerobe Vol.73 (2022). doi:10.1016/j.anaerobe.2021.102505 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85030
Title
Antimicrobial-resistant Bacteroides fragilis in Thailand and their inhibitory effect in vitro on the growth of Clostridioides difficile
Author(s)
Other Contributor(s)
Abstract
Objectives: The aim of this study was to investigate antimicrobial-resistant Bacteroides fragilis in Thailand and possible effects of such strains on human health and disease. Methods: Phenotypic antimicrobial susceptibility testing was performed on 17 clinical B. fragilis isolates. The genome of one isolate was sequenced and analysed to explore its resistance genotype. An in vitro growth assay was conducted to evaluate the inhibitory effect of B. fragilis on Clostridioides difficile. Results: There was a high prevalence of clindamycin (71%), meropenem (47%) and moxifloxacin (29%) resistance. Most strains remained susceptible to metronidazole, but one had high-level metronidazole resistance conferred by a nimD-containing plasmid. B. fragilis displayed an in vitro inhibitory effect on the growth of C. difficile and a drug-resistant strain retained this inhibition in the presence of clindamycin. Conclusions: Antimicrobial resistance was seen in Thai B. fragils isolates, which may help protect the host against C. difficile infection.