Early-onset pancreatic cancer and associated metabolic risk factors in the Middle East and North Africa: A 20-year analysis of the Global Burden of Disease Study
Issued Date
2024-01-01
Resource Type
ISSN
02548860
eISSN
09750711
Scopus ID
2-s2.0-85197649354
Journal Title
Indian Journal of Gastroenterology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Indian Journal of Gastroenterology (2024)
Suggested Citation
Danpanichkul P., Uawithya E., Lopimpisuth C., Sukphutanan B., Kulthamrongsri N., Aboona M.B., Duangsonk K., Lau S., Simadibrata D.M., Daggag H., Wallace M.B., Wijarnpreecha K. Early-onset pancreatic cancer and associated metabolic risk factors in the Middle East and North Africa: A 20-year analysis of the Global Burden of Disease Study. Indian Journal of Gastroenterology (2024). doi:10.1007/s12664-024-01626-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99630
Title
Early-onset pancreatic cancer and associated metabolic risk factors in the Middle East and North Africa: A 20-year analysis of the Global Burden of Disease Study
Author's Affiliation
Sheikh Shakhbout Medical City
Siriraj Hospital
TTUHSC School of Medicine
Universitas Indonesia
Faculty of Medicine, Chiang Mai University
University of Miami
Mayo Clinic Scottsdale-Phoenix, Arizona
Imperial College London
University of Arizona College of Medicine – Phoenix
MetroWest Medical Center
Mayo Clinic
Banner - University Medical Center Phoenix
Mayo Clinic in Jacksonville, Florida
Siriraj Hospital
TTUHSC School of Medicine
Universitas Indonesia
Faculty of Medicine, Chiang Mai University
University of Miami
Mayo Clinic Scottsdale-Phoenix, Arizona
Imperial College London
University of Arizona College of Medicine – Phoenix
MetroWest Medical Center
Mayo Clinic
Banner - University Medical Center Phoenix
Mayo Clinic in Jacksonville, Florida
Corresponding Author(s)
Other Contributor(s)
Abstract
Background and Objective: Early-onset pancreatic cancer (EOPC) is associated with poor prognosis and high disease burden. Metabolic risk factors such as diabetes and obesity are considered risk factors of EOPC. Recently, there has been an increasing number of EOPCs worldwide. However, the analysis of EOPC, including its metabolic risk factors, in the Middle East and North Africa (MENA) region has not been fully addressed. Methods: Data from the Global Burden of Disease Study between 2000 and 2019 was used to analyze the prevalence, incidence, deaths and disability-adjusted life years (DALYs) associated with EOPC and its metabolic risk factors. The analysis further categorized the data based on countries, income status and sex and examined the annual percentage change (APC). Results: Approximately 2800 cases, 2400 deaths and 114,000 DALYs were attributable to EOPC in the MENA region. The incidence (APC + 3.42%), death (APC + 0.73%) and DALYs (APC + 3.23%) rates of EOPC increased. In addition, the death and DALY rates of EOPC attributable to obesity and diabetes increased. High and upper-middle-income countries exhibited a higher burden of EOPC than lower-income countries. Conclusion: Over the past two decades, the burden of EOPC and its associated metabolic risk factors has increased. There is an urgent need for region-wide policy development, including screening methods and risk factor reduction, to mitigate the high and rising burden of EOPC in the MENA region. Graphical Abstract: (Figure presented.).