Incidence of Respiratory Syncytial Virus–Associated Lower Respiratory Tract Illness in Infants in Low- and Middle-Income Regions During the Coronavirus Disease 2019 Pandemic
Issued Date
2023-12-01
Resource Type
eISSN
23288957
Scopus ID
2-s2.0-85180267442
Journal Title
Open Forum Infectious Diseases
Volume
10
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Open Forum Infectious Diseases Vol.10 No.12 (2023)
Suggested Citation
Fry S., Chokephaibulkit K., Pallem S., Henry O., Pu Y., Akawung A., Kim J.H., Yanni E., Tullio A.N., Aurpibul L., Fong Lee C.M., Ceballos A., Zaman K., de Regalado I.A., Ahmed K., Arias Fernandez D.A., Taher S.W., Caccavo J., Coutinho C.M., D’Andrea Nores U., De León T., D’Silva E.C., De Bernardi M., Dieser P., Falaschi A., del Carmen Flores Acosta C., Gentile A., Teo I.H., Kotze S., López-Medina E., Luca R., Lucion M.F., Mantaring J.B.V., Marín B., Moelo M., Mussi-Pinhata M.M., Pinto J., Puthanakit T., Reyes O., Roa M.F., Rodriguez Brieschke M.T., Rodriguez C.E., Rodriguez Niño J.N., Schwarzbold A.V., Garcia A.S., Sivapatham L., Soon R., Tinoco J.C., Velásquez Penagos J.A., Santos G.D. Incidence of Respiratory Syncytial Virus–Associated Lower Respiratory Tract Illness in Infants in Low- and Middle-Income Regions During the Coronavirus Disease 2019 Pandemic. Open Forum Infectious Diseases Vol.10 No.12 (2023). doi:10.1093/ofid/ofad553 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95771
Title
Incidence of Respiratory Syncytial Virus–Associated Lower Respiratory Tract Illness in Infants in Low- and Middle-Income Regions During the Coronavirus Disease 2019 Pandemic
Author(s)
Fry S.
Chokephaibulkit K.
Pallem S.
Henry O.
Pu Y.
Akawung A.
Kim J.H.
Yanni E.
Tullio A.N.
Aurpibul L.
Fong Lee C.M.
Ceballos A.
Zaman K.
de Regalado I.A.
Ahmed K.
Arias Fernandez D.A.
Taher S.W.
Caccavo J.
Coutinho C.M.
D’Andrea Nores U.
De León T.
D’Silva E.C.
De Bernardi M.
Dieser P.
Falaschi A.
del Carmen Flores Acosta C.
Gentile A.
Teo I.H.
Kotze S.
López-Medina E.
Luca R.
Lucion M.F.
Mantaring J.B.V.
Marín B.
Moelo M.
Mussi-Pinhata M.M.
Pinto J.
Puthanakit T.
Reyes O.
Roa M.F.
Rodriguez Brieschke M.T.
Rodriguez C.E.
Rodriguez Niño J.N.
Schwarzbold A.V.
Garcia A.S.
Sivapatham L.
Soon R.
Tinoco J.C.
Velásquez Penagos J.A.
Santos G.D.
Chokephaibulkit K.
Pallem S.
Henry O.
Pu Y.
Akawung A.
Kim J.H.
Yanni E.
Tullio A.N.
Aurpibul L.
Fong Lee C.M.
Ceballos A.
Zaman K.
de Regalado I.A.
Ahmed K.
Arias Fernandez D.A.
Taher S.W.
Caccavo J.
Coutinho C.M.
D’Andrea Nores U.
De León T.
D’Silva E.C.
De Bernardi M.
Dieser P.
Falaschi A.
del Carmen Flores Acosta C.
Gentile A.
Teo I.H.
Kotze S.
López-Medina E.
Luca R.
Lucion M.F.
Mantaring J.B.V.
Marín B.
Moelo M.
Mussi-Pinhata M.M.
Pinto J.
Puthanakit T.
Reyes O.
Roa M.F.
Rodriguez Brieschke M.T.
Rodriguez C.E.
Rodriguez Niño J.N.
Schwarzbold A.V.
Garcia A.S.
Sivapatham L.
Soon R.
Tinoco J.C.
Velásquez Penagos J.A.
Santos G.D.
Author's Affiliation
Faculty of Health Sciences
Siriraj Hospital
Centro Médico Imbanaco
GlaxoSmithKline Pharmaceuticals SA/NV
Hospital De San José, Bogotá, Colombia
GlaxoSmithKline, USA
Hospital General de Durango
University of the Philippines Manila
Fundacion Santa Fe de Bogota
Universidad de Los Andes, Colombia
Universidade Federal de Santa Maria
Universidade Federal de Minas Gerais
Hospital Universitario Dr. Jose Eleuterio Gonzalez
Hospital de Ninos Ricardo Gutierrez
Hospital Santojanni, Buenos Aires
International Centre for Diarrhoeal Disease Research Bangladesh
Sarawak General Hospital
Universidade de São Paulo
Faculty of Medicine, Chulalongkorn University
Stellenbosch University
Chiang Mai University
Maternity Hospital José Domingo De Obaldia
Centro de Vacunación Internacional S.A.
Policentro de Salud de Juan Diaz
Hospital Santo Tomás
Member of the Sistema Nacional de investigadores de Panamá (SNI)
Hospital Pediátrico Alexander Fleming y Hospital Dr. Ramón Carrillo
Ampang Hospital
Setshaba Research Centre
Universidad del Valle
Synexus Watermeyer Clinical Research Centre
Hospital Universitario San Vicente Fundación
Hospital Diego Paroissien
Instituto Médico Río Cuarto
Ampang Hospital
Sabah Women and Children's Hospital
Hospital Donación F. Santojanni
Simpang Kuala Health Clinic
Siriraj Hospital
Centro Médico Imbanaco
GlaxoSmithKline Pharmaceuticals SA/NV
Hospital De San José, Bogotá, Colombia
GlaxoSmithKline, USA
Hospital General de Durango
University of the Philippines Manila
Fundacion Santa Fe de Bogota
Universidad de Los Andes, Colombia
Universidade Federal de Santa Maria
Universidade Federal de Minas Gerais
Hospital Universitario Dr. Jose Eleuterio Gonzalez
Hospital de Ninos Ricardo Gutierrez
Hospital Santojanni, Buenos Aires
International Centre for Diarrhoeal Disease Research Bangladesh
Sarawak General Hospital
Universidade de São Paulo
Faculty of Medicine, Chulalongkorn University
Stellenbosch University
Chiang Mai University
Maternity Hospital José Domingo De Obaldia
Centro de Vacunación Internacional S.A.
Policentro de Salud de Juan Diaz
Hospital Santo Tomás
Member of the Sistema Nacional de investigadores de Panamá (SNI)
Hospital Pediátrico Alexander Fleming y Hospital Dr. Ramón Carrillo
Ampang Hospital
Setshaba Research Centre
Universidad del Valle
Synexus Watermeyer Clinical Research Centre
Hospital Universitario San Vicente Fundación
Hospital Diego Paroissien
Instituto Médico Río Cuarto
Ampang Hospital
Sabah Women and Children's Hospital
Hospital Donación F. Santojanni
Simpang Kuala Health Clinic
Corresponding Author(s)
Other Contributor(s)
Abstract
Background. Incidence data of respiratory syncytial virus–associated lower respiratory tract illness (RSV-LRTI) are sparse in low- and middle-income countries (LMICs). We estimated RSV-LRTI incidence rates (IRs) in infants in LMICs using World Health Organization case definitions. Methods. This prospective cohort study, conducted in 10 LMICs from May 2019 to October 2021 (largely overlapping with the coronavirus disease 2019 [COVID-19] pandemic), followed infants born to women with low-risk pregnancies for 1 year from birth using active and passive surveillance to detect potential LRTIs, and quantitative reverse-transcription polymerase chain reaction on nasal swabs to detect RSV. Results. Among 2094 infants, 32 (1.5%) experienced an RSV-LRTI (8 during their first 6 months of life, 24 thereafter). Seventeen (0.8%) infants had severe RSV-LRTI and 168 (8.0%) had all-cause LRTI. IRs (95% confidence intervals [CIs]) of first RSV-LRTI episode were 1.0 (.3–2.3), 0.8 (.3–1.5), and 1.6 (1.1–2.2) per 100 person-years for infants aged 0–2, 0–5, and 0–11 months, respectively. IRs (95% CIs) of the first all-cause LRTI episode were 10.7 (8.1–14.0), 11.7 (9.6–14.0), and 8.7 (7.5–10.2) per 100 person-years, respectively. IRs varied by country (RSV-LRTI: 0.0–8.3, all-cause LRTI: 0.0–49.6 per 100 person-years for 0- to 11-month-olds). Conclusions. RSV-LRTI IRs in infants in this study were relatively low, likely due to reduced viral circulation caused by COVID-19–related nonpharmaceutical interventions.