Effects of BHA or DHEA on DHPN-induced carcinogenesis in opisthorchis vierrine-infected syrian golden hamsters
4
Issued Date
2024
Copyright Date
1992
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
viii, 85 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Pathobiology))--Mahidol University, 1992
Suggested Citation
Jiranun Ngernprayoon Effects of BHA or DHEA on DHPN-induced carcinogenesis in opisthorchis vierrine-infected syrian golden hamsters. Thesis (M.Sc. (Pathobiology))--Mahidol University, 1992. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99820
Title
Effects of BHA or DHEA on DHPN-induced carcinogenesis in opisthorchis vierrine-infected syrian golden hamsters
Alternative Title(s)
ผลของบีเอชเอและดีเอชอีต่อการเกิดมะเร็งที่ชักนำด้วยดีเอชพีเอ็นในซีเรียนโกลเดน แฮมเตอร์ที่ได้รับพยาธิใบไม้ในตับโอพีสโตคิสวิเวอร์รินี
Author(s)
Abstract
Cholangiocarcinoma is a unique bile duct cancer with highest incidence in the northeast of Thailand. The tumor is associated with the endemic liver fluke, Opisthorchis viverrini, infection. Development of cholangiocarcinoma in man was attributable to the synergistic action of both nitrosamines which is believed of its presence in fermented fish called Pla-rha, and the liver fluke infection. Experimental results supported those suspects and revealed the initiation role of nitrosamines and strong promotion effects of the parasite. The present study aimed to investigate the possible modifying effect of food additive, BHA and the adrenal steroid DHEA in hamster liver initiated with DHPN followed by 0. viverrini infection. The animals were divided into 8 groups: group 1, DHPN 750 mg/kg + 60 P; group 2, DHPN 750 mg/kg + 60 P+DHEA 0.6% ; group 3, DHPN 750 mg/kg + 60 P+BHA 1% ; group 4, 60 P; group 5, DHPN 750 mg/kg ; group 6, DHPN 750 mg/kg + DHEA 0.6% ; group 7, DHPN 750 mg/kg + BHA 1% ; group 8, untreated control. BHA and DHEA did not show any effect on cholangio carcinogenesis induced by DHPN and the parasite. DHEA also did not show any modifying effect on the development of hepatic nodules, only BHA decrease both the incidence and number per animal of their lesion. However, the mechanism of BHA inhibition of hepatocellular carcinogenesis is not yet clear.
Description
Pathobiology (Mahidol University 1992)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Pathobiology
Degree Grantor(s)
Mahidol University