Are oral lichen planus patients at high risk of hepatitis C? A case-control study
Issued Date
2022-06-01
Resource Type
eISSN
24687855
Scopus ID
2-s2.0-85111891568
Pubmed ID
34332181
Journal Title
Journal of Stomatology, Oral and Maxillofacial Surgery
Volume
123
Issue
3
Start Page
e37
End Page
e42
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Stomatology, Oral and Maxillofacial Surgery Vol.123 No.3 (2022) , e37-e42
Suggested Citation
Pitak-Arnnop P., Subbalekha K., Sirintawat N., Tangmanee C., Auychai P., Muangchan C., Sukphopetch P., Meningaud J.P., Neff A. Are oral lichen planus patients at high risk of hepatitis C? A case-control study. Journal of Stomatology, Oral and Maxillofacial Surgery Vol.123 No.3 (2022) , e37-e42. e42. doi:10.1016/j.jormas.2021.07.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84442
Title
Are oral lichen planus patients at high risk of hepatitis C? A case-control study
Other Contributor(s)
Abstract
Objective: To assess the correlation between oral lichen planus (OLP) and viral hepatitis C (HCV). Methods: This retrospective case-control study included a sample of OLP patients in a 3-year interval. The predictor variable was the presence of OLP (yes/no). The outcome variable was the diagnosis of HCV. Other study variables were grouped into demographic, anatomic, and clinical. Descriptive, bi- and multivariate statistics were computed with a significant level at P ≤ 0.05. Results: The sample was composed of 237 OLP patients (38.8% females) with a mean age of 59.9 ± 17.8 years (range, 17-96), and 948 age- and gender-matched control individuals. The significant higher frequency of HCV was identified in OLP patients (frequency: 19.8% vs. 2.1%; adjusted matched odds ratio [mORadj], 9.5; 95% confidence interval [95% CI], 5.98 to 15.91; P < 0.0001; Pearson's Phi coefficient [rphi], 0.307). In the adjusted model, OLP with HCV was associated with 1) oro-cutaneous manifestations (mORadj, 17.58; 95% CI, 1.92 to 161.26; P = 0.0059; Bayesian posterior probability of positive test [Wp], 96%), 2) any intraoral forms other than reticular/plaque-liked forms (mORadj, 0.09; 95% CI, 0.04 to 0.18; P < 0.0001; Wp, 52%), and 3) poor response to topical corticosteroids (mORadj, 0.05; 95% CI, 0.02 to 0.16; P < 0.0001; Wp, 88%). Conclusions: OLP, especially oro-cutaneous disease or steroid-refractory OLP, are associated with an increased frequency of HCV. Not only HCV screening in OLP patients, but oral examination in HCV patients, are both recommended as primary preventive measures.