Selected Alu methylation levels in the gastric carcinogenesis cascade
Issued Date
2025-01-01
Resource Type
eISSN
21678359
Scopus ID
2-s2.0-105005515238
Journal Title
PeerJ
Volume
13
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
PeerJ Vol.13 No.5 (2025)
Suggested Citation
Meevassana J., Vongsuly C.W., Nakbua T., Kamolratanakul S., Thitiwanichpiwong P., Bin-Alee F., Keelawat S., Kitkumthorn N. Selected Alu methylation levels in the gastric carcinogenesis cascade. PeerJ Vol.13 No.5 (2025). doi:10.7717/peerj.19485 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110353
Title
Selected Alu methylation levels in the gastric carcinogenesis cascade
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Genome-wide hypomethylation, a common epigenetic change that occurs during cancer development, primarily affects repetitive elements, such as Alu repeats. Consequently, Alu repeats can be used as a surrogate marker of genomic hypomethylation. Methods: In this study, we aimed to investigate the correlation between Alu methylation levels and the multistage course of gastric carcinogenesis. Results: We found that the Alu methylation levels in gastric cancer tissue decreased compared with those in normal gastric tissue, with the change in methylation levels and pattern being most significant between chronic gastritis and intestinal metaplasia. Moreover, Alu methylation levels were not associated with Helicobacter pylori or Epstein–Barr virus infection. Conclusions: Finally, our sensitivity and specificity analyses suggested that Alu methylation level can be used to distinguish gastric cancer tissue from normal tissue. Thus, Alu methylation level shows promise as biomarker for gastric cancer diagnosis.