Lidocaine Reducing Pain from Benzathine Penicillin Injection: A Controlled Trial
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Issued Date
2022-10-01
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-85139991017
Journal Title
Siriraj Medical Journal
Volume
74
Issue
10
Start Page
699
End Page
704
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.74 No.10 (2022) , 699-704
Suggested Citation
Jiamton S., Jantanapornchai N., Nokdhes Y.N., Patthamalai P., Tantrapornpong P., Nanchaipruek Y., Limpoka P. Lidocaine Reducing Pain from Benzathine Penicillin Injection: A Controlled Trial. Siriraj Medical Journal Vol.74 No.10 (2022) , 699-704. 704. doi:10.33192/Smj.2022.82 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85477
Title
Lidocaine Reducing Pain from Benzathine Penicillin Injection: A Controlled Trial
Author's Affiliation
Other Contributor(s)
Abstract
Objective: This study aimed to investigate the efficacy and safety of benzathine penicillin G (BPG) injection compared between dilution with 1% lidocaine hydrochloride and dilution with sterile water to reduce pain in Thai male syphilis patients. Materials and Methods: This randomized, split-buttock, double-blind controlled trial was conducted at the Sexually Transmitted Disease and HIV Division, Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during September 2018 to July 2019. After randomization, 20 left and 20 right buttocks were injected with 1.2 million-unit BPG (half dose) with lidocaine as the diluent. The other 20 left and 20 right buttocks were then injected with 1.2 million-unit BPG (half dose) with sterile water as the diluent. Pain at each buttock was measured by numeric rating scale during and immediately after the injection, and at 5 minutes, 20 minutes, and 24 hours after injection. Results: Forty males (mean age: 30.6±10.3 years) were included. Compared to sterile water diluent, we found that dilution with 1% lidocaine significantly reduced pain during and immediately after injection, and at 5-minutes and 20-minutes post-injection (all p<0.001). There was no significant improvement in pain at 24-hours post-injection. Minor adverse events were observed in 37.5% of patients, including generalized rash, pruritus, and fever. One patient experienced minor drug allergy. Conclusion: One percent lidocaine as a diluent of BPG was found to be effective for reducing pain during and after BPG injection.