Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters
9
Issued Date
2023-01-01
Resource Type
eISSN
11791454
Scopus ID
2-s2.0-85146888743
Journal Title
Journal of Experimental Pharmacology
Volume
15
Start Page
13
End Page
26
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Experimental Pharmacology Vol.15 (2023) , 13-26
Suggested Citation
Kongratanapasert T., Kongsomros S., Arya N., Sutummaporn K., Wiriyarat W., Akkhawattanangkul Y., Boonyarattanasoonthorn T., Asavapanumas N., Kanjanasirirat P., Suksatu A., Sa-Ngiamsuntorn K., Borwornpinyo S., Vivithanaporn P., Chutipongtanate S., Hongeng S., Ongphiphadhanakul B., Thitithanyanont A., Khemawoot P., Sritara P. Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters. Journal of Experimental Pharmacology Vol.15 (2023) , 13-26. 26. doi:10.2147/JEP.S382895 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82233
Title
Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters
Author(s)
Kongratanapasert T.
Kongsomros S.
Arya N.
Sutummaporn K.
Wiriyarat W.
Akkhawattanangkul Y.
Boonyarattanasoonthorn T.
Asavapanumas N.
Kanjanasirirat P.
Suksatu A.
Sa-Ngiamsuntorn K.
Borwornpinyo S.
Vivithanaporn P.
Chutipongtanate S.
Hongeng S.
Ongphiphadhanakul B.
Thitithanyanont A.
Khemawoot P.
Sritara P.
Kongsomros S.
Arya N.
Sutummaporn K.
Wiriyarat W.
Akkhawattanangkul Y.
Boonyarattanasoonthorn T.
Asavapanumas N.
Kanjanasirirat P.
Suksatu A.
Sa-Ngiamsuntorn K.
Borwornpinyo S.
Vivithanaporn P.
Chutipongtanate S.
Hongeng S.
Ongphiphadhanakul B.
Thitithanyanont A.
Khemawoot P.
Sritara P.
Author's Affiliation
Other Contributor(s)
Abstract
Background: The outbreak of COVID-19 has led to the suffering of people around the world, with an inaccessibility of specific and effective medication. Fingerroot extract, which showed in vitro anti-SARS-CoV-2 activity, could alleviate the deficiency of antivirals and reduce the burden of health systems. Aim of Study: In this study, we conducted an experiment in SARS-CoV-2-infected hamsters to determine the efficacy of fingerroot extract in vivo. Materials and Methods: The infected hamsters were orally administered with vehicle control, fingerroot extract 300 or 1000 mg/kg, or favipiravir 1000 mg/kg at 48 h post-infection for 7 consecutive days. The hamsters (n = 12 each group) were sacrificed at day 2, 4 and 8 post-infection to collect the plasma and lung tissues for analyses of viral output, lung histology and lung concentration of panduratin A. Results: All animals in treatment groups reported no death, while one hamster in the control group died on day 3 post-infection. All treatments significantly reduced lung pathophysiology and inflammatory mediators, PGE2 and IL-6, compared to the control group. High levels of panduratin A were found in both the plasma and lung of infected animals. Conclusion: Fingerroot extract was shown to be a potential of reducing lung inflammation and cytokines in hamsters. Further studies of the full pharmacokinetics and toxicity are required before entering into clinical development.