Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action
Issued Date
2022-05-01
Resource Type
ISSN
07533322
eISSN
19506007
Scopus ID
2-s2.0-85127346156
Pubmed ID
35367766
Journal Title
Biomedicine and Pharmacotherapy
Volume
149
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomedicine and Pharmacotherapy Vol.149 (2022)
Suggested Citation
Mitra S., Anjum J., Muni M., Das R., Rauf A., Islam F., Bin Emran T., Semwal P., Hemeg H.A., Alhumaydhi F.A., Wilairatana P. Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action. Biomedicine and Pharmacotherapy Vol.149 (2022). doi:10.1016/j.biopha.2022.112877 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86866
Title
Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action
Other Contributor(s)
Abstract
Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants, molds, and lichens. Emodin has been used as a traditional medication for more than 2000 years and is still common in numerous herbal drugs. Emodin is plentiful in the three plant families, including Polygonaceae (Rheum, Rumex, and Polygonum spp.), Fabaceae (Cassia spp.), and Rhamnaceae (Rhamnus, Frangula, and Ventilago spp.). Emerging experimental evidences indicate that emodin confers a wide range of pharmacological activities; special focus was implemented toward neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, anxiety and depression, schizophrenia, chronic hyperglycemic peripheral neuropathy, etc. Numerous preclinical evidences were established in support of the neuroprotection of emodin. However, this review highlighted the role of emodin as a potent neurotherapeutic agent; therefore, its evidence-based functionality on neurological disorders (NDs).