Cell-Mediated Immunity to plasmodium VIVAX infection
2
Issued Date
2004
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Kulachart Jangpatarapongsa, Jeeraphat Sirichaisinthop, Jetsumon Sattabongkot, Sornchai Looareesuwan, ศรชัย หลูอารีย์สุวรรณ, Marita Troye-Blomberg, Rachanee Udomsangpetch (2004). Cell-Mediated Immunity to plasmodium VIVAX infection. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/63376
Title
Cell-Mediated Immunity to plasmodium VIVAX infection
Abstract
Immunity induced by P. vivax during acute infection leads to memory T cells recruitment of
which will be activated during subsequent infection. This study therefore aims to verify the
level of memory T cells during acute and convalescent periods. Memory T cells are recognized
by the surface molecules CD45RO+ CD27+ as an early stage and CD27- as a mature stage. The
results showed significant [P<0.01] increase of mean percentage of CD4+ memory T cells during
acute infection when compared with those either from healthy donors and immune villagers.
The P. vivax-induced memory T cells were maintained at high level until 60 days post treatment.
The mean percentage of CD8+ memory T cells was also significantly higher during acute infection
until 60 days post treatment. Interestingly, the CD8+ memory T cells was stably maintained at
high level among the non-acute malaria immune villagers in contrast to the low level CD4+
memory T cells in the same immune villager group. These results suggest that memory T cells
particularly CD8+ phenotype-play role in the development of naturally acquired protection
against P. vivax infection. The ongoing study will investigate further whether or not the protection
is mediated by the memory T cells of ab-phenotype
Description
Joint International Tropical Medicine Meeting 2004: Ambassador Hotel, Thailand 29 November-1 December 2004: abstract. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2004. p.201.