Porcine placenta extract induced Akt, ERK, and JNK signaling to heighten the osteogenic activity of human osteoblasts
Issued Date
2022-08-01
Resource Type
eISSN
22313354
Scopus ID
2-s2.0-85135557190
Journal Title
Journal of Applied Pharmaceutical Science
Volume
12
Issue
8
Start Page
18
End Page
25
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Applied Pharmaceutical Science Vol.12 No.8 (2022) , 18-25
Suggested Citation
Songjang W., Nensat C., Tohtong R., Suthiphongchai T., Phimsen S., Rattanasinganchan P., Metheenukul P., Kasekarn W., Jiraviriyakul A. Porcine placenta extract induced Akt, ERK, and JNK signaling to heighten the osteogenic activity of human osteoblasts. Journal of Applied Pharmaceutical Science Vol.12 No.8 (2022) , 18-25. 25. doi:10.7324/JAPS.2022.120803 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85663
Title
Porcine placenta extract induced Akt, ERK, and JNK signaling to heighten the osteogenic activity of human osteoblasts
Author's Affiliation
Other Contributor(s)
Abstract
Porcine placenta extract (PPE) is an effective pharmaceutical and cosmetic ingredient, despite its high bioavailability. Despite this, only a few studies on the extract's effect on human osteoblast cellular behavior have been conducted. This study used hFOB 1.19 cells to demonstrate the mechanism by which a novel potent osteogenic compound that was discovered by stimulating the growth, alkaline phosphatase secretion, mineralization, and osteogenesis markers of human osteoblast hFOB 1.19 cells resulted in significant increases in extracellular signal-regulated kinase (ERK)1/2, Akt, and c-Jun N-terminal kinase (JNK) phosphorylation. In addition, PPE was discovered to significantly increase in vitro bone formation that may provide the beneficial potential for osteoporosis prevention and treatment.