Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review
Issued Date
2023-09-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85170343718
Pubmed ID
37687232
Journal Title
Molecules (Basel, Switzerland)
Volume
28
Issue
17
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules (Basel, Switzerland) Vol.28 No.17 (2023)
Suggested Citation
Iqbal I., Wilairatana P., Saqib F., Nasir B., Wahid M., Latif M.F., Iqbal A., Naz R., Mubarak M.S. Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review. Molecules (Basel, Switzerland) Vol.28 No.17 (2023). doi:10.3390/molecules28176403 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90050
Title
Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review
Other Contributor(s)
Abstract
Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites which may be considered non-essential nutrients but have medicinal importance. These dietary phytochemicals exhibit chemopreventive and therapeutic effects against numerous diseases. Polyphenols are secondary metabolites found in vegetables, fruits, and grains. These compounds exhibit several health benefits such as immune modulators, vasodilators, and antioxidants. This review focuses on recent studies on using dietary polyphenols to treat cardiovascular disorders, atherosclerosis, and vascular endothelium deficits. We focus on exploring the safety of highly effective polyphenols to ensure their maximum impact on cardiac abnormalities and discuss recent epidemiological evidence and intervention trials related to these properties. Kaempferol, quercetin, and resveratrol prevent oxidative stress by regulating proteins that induce oxidation in heart tissues. In addition, polyphenols modulate the tone of the endothelium of vessels by releasing nitric oxide (NO) and reducing low-density lipoprotein (LDL) oxidation to prevent atherosclerosis. In cardiomyocytes, polyphenols suppress the expression of inflammatory markers and inhibit the production of inflammation markers to exert an anti-inflammatory response. Consequently, heart diseases such as strokes, hypertension, heart failure, and ischemic heart disease could be prevented by dietary polyphenols.