RECENT DEVELOPMENT OF MACHINE LEARNING-BASED METHODS FOR THE PREDICTION OF DEFENSIN FAMILY AND SUBFAMILY
Issued Date
2022-01-03
Resource Type
eISSN
16112156
Scopus ID
2-s2.0-85130258167
Journal Title
EXCLI Journal
Volume
21
Start Page
757
End Page
771
Rights Holder(s)
SCOPUS
Bibliographic Citation
EXCLI Journal Vol.21 (2022) , 757-771
Suggested Citation
Charoenkwan P., Schaduangrat N., Hasan Mahmud S.M., Thinnukool O., Shoombuatong W. RECENT DEVELOPMENT OF MACHINE LEARNING-BASED METHODS FOR THE PREDICTION OF DEFENSIN FAMILY AND SUBFAMILY. EXCLI Journal Vol.21 (2022) , 757-771. 771. doi:10.17179/excli2022-4913 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83861
Title
RECENT DEVELOPMENT OF MACHINE LEARNING-BASED METHODS FOR THE PREDICTION OF DEFENSIN FAMILY AND SUBFAMILY
Author's Affiliation
Other Contributor(s)
Abstract
Nearly all living species comprise of host defense peptides called defensins, that are crucial for innate immunity. These peptides work by activating the immune system which kills the microbes directly or indirectly, thus providing protection to the host. Thus far, numerous preclinical and clinical trials for peptide-based drugs are currently being evaluated. Although, experimental methods can help to precisely identify the defensin peptide family and subfamily, these approaches are often time-consuming and cost-ineffective. On the other hand, machine learning (ML) methods are able to effectively employ protein sequence information without the knowledge of a protein’s three-dimensional structure, thus highlighting their predictive ability for the large-scale identification. To date, several ML methods have been developed for the in silico identification of the defensin peptide family and subfamily. Therefore, summarizing the advantages and disadvantages of the existing methods is urgently needed in order to provide useful suggestions for the development and improvement of new computational models for the identification of the defensin peptide family and subfamily. With this goal in mind, we first provide a comprehensive survey on a collection of six state-of-the-art computational approaches for predicting the defensin peptide family and subfamily. Herein, we cover different important aspects, including the dataset quality, feature encoding methods, feature selection schemes, ML algorithms, cross-validation methods and web server availability/usability. Moreover, we provide our thoughts on the limitations of existing methods and future perspectives for improving the prediction performance and model interpretability. The insights and suggestions gained from this review are anticipated to serve as a valuable guidance for researchers for the development of more robust and useful predictors.