Generation of human induced pluripotent stem cell line (MUi033-A) from a male with homozygous for Hemoglobin E
Issued Date
2023-12-01
Resource Type
ISSN
18735061
eISSN
18767753
Scopus ID
2-s2.0-85174920107
Journal Title
Stem Cell Research
Volume
73
Rights Holder(s)
SCOPUS
Bibliographic Citation
Stem Cell Research Vol.73 (2023)
Suggested Citation
Tong-ngam P., Wongkummool W., Pongpaksupasin P., Rawara N., Kovanich D., Kitiyanant N., Munkongdee T., Paiboonsukwong K., Fucharoen S., Tubsuwan A. Generation of human induced pluripotent stem cell line (MUi033-A) from a male with homozygous for Hemoglobin E. Stem Cell Research Vol.73 (2023). doi:10.1016/j.scr.2023.103228 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90891
Title
Generation of human induced pluripotent stem cell line (MUi033-A) from a male with homozygous for Hemoglobin E
Other Contributor(s)
Abstract
Hemoglobin E (HbE), a common variant in Southeast Asian populations, results from a G to A substitution at codon 26 of the HBB gene, causing abnormal Hb and mild β-thalassemia-like symptoms. Here, we derived an induced pluripotent stem cell (iPSC) line, named MUi033-A, from a male homozygous for HbE. The iPSC line demonstrates a normal karyotype and embryonic stem cell-like properties including pluripotency gene expression, and tri-lineage differentiation potential. This iPSC resource holds the potential for investigating gene therapy targeting HbE mutation.