Sleep-Related Hypoventilation Syndromes
Issued Date
2022-01-01
Resource Type
Scopus ID
2-s2.0-85163419923
Journal Title
Paediatric Sleep Disorders: Case-based Practical Guide
Start Page
93
End Page
105
Rights Holder(s)
SCOPUS
Bibliographic Citation
Paediatric Sleep Disorders: Case-based Practical Guide (2022) , 93-105
Suggested Citation
Preutthipan A. Sleep-Related Hypoventilation Syndromes. Paediatric Sleep Disorders: Case-based Practical Guide (2022) , 93-105. 105. doi:10.1007/978-981-19-5791-8_10 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87974
Title
Sleep-Related Hypoventilation Syndromes
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
During sleep, ventilation in a normal man is generally decreased. The tidal volume and respiratory rate are both reduced compared to wakefulness. Minute ventilation is significantly less in all stages of sleep, particularly in rapid-eye-movement (REM) sleep. Moreover, reduction in upper airway muscle tone during sleep results in increasing upper airway resistance and risk of obstructive sleep apnea. Hypoxic and hypercapnic ventilatory drives also decrease during sleep. As a result, normal adults and children when asleep have a reduction in oxygen saturation and increased carbon dioxide levels. In this chapter we will focus on congenital central alveolar hypoventilation syndrome (CCHS) and obesity hypoventilation syndrome (OHS), which are more commonly found in pediatric practice than the other sleep-related hypoventilation disorders.