iPSC-based approach for human hair follicle regeneration
Issued Date
2023-01-01
Resource Type
eISSN
2296634X
Scopus ID
2-s2.0-85162033358
Journal Title
Frontiers in Cell and Developmental Biology
Volume
11
Rights Holder(s)
SCOPUS
Bibliographic Citation
Frontiers in Cell and Developmental Biology Vol.11 (2023)
Suggested Citation
Vatanashevanopakorn C., Sartyoungkul T. iPSC-based approach for human hair follicle regeneration. Frontiers in Cell and Developmental Biology Vol.11 (2023). doi:10.3389/fcell.2023.1149050 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87670
Title
iPSC-based approach for human hair follicle regeneration
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Hair follicles (HFs) are a multifunctional structure involved in physical protection, thermoregulation, sensational detection, and wound healing. Formation and cycling of HFs require dynamic interaction between different cell types of the follicles. Although the processes have been well studied, the generation of human functional HFs with a normal cycling pattern for clinical utilization has yet to be achieved. Recently, human pluripotent stem cells (hPSCs) serve as an unlimited cell source for generating various types of cells including cells of the HFs. In this review, HF morphogenesis and cycling, different cell sources used for HF regeneration, and potential strategies for HF bioengineering using induced pluripotent stem cells (iPSCs) are depicted. Challenges and perspectives toward the therapeutic use of bioengineered HFs for hair loss disorder are also discussed.