Association of neck circumference with diabetes mellitus and hypertension : a systematic review and meta-analysis
Issued Date
2024
Copyright Date
2020
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xvi, 199 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Medical Epidemiology))--Mahidol University, 2015
Suggested Citation
Tiwari, Sagar, 1989- Association of neck circumference with diabetes mellitus and hypertension : a systematic review and meta-analysis. Thesis (M.Sc. (Medical Epidemiology))--Mahidol University, 2015. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/92109
Title
Association of neck circumference with diabetes mellitus and hypertension : a systematic review and meta-analysis
Author(s)
Abstract
Several studies have suggested that neck circumference (NC) can be used as screening measures for diagnosing obesity-related metabolic complications and might be associated with type 2 diabetes mellitus (T2D) and hypertension (HT) but their results are conflicting. Therefore, we conducted this systematic review and meta-analysis to assess the overall association of NC with T2D and HT in adults. Studies were identified from MEDLINE and Scopus database up to December 2019. The exposure of measurement, i.e., NC could be categorical (high vs low) and continuous data. Clinical outcomes for T2D and HT could be dichotomous data or continuous values, e.g., fasting blood sugar (FBS), glycated hemoglobin (HBA1c), systolic blood pressure (SBP), and diastolic blood pressure (DBP). We included observational studies conducted in adult reporting odds ratio (OR) along with 95% confidence interval (CI) for risk of T2D or HT and correlation coefficient of NC with FBS, HBA1c, SBP, and DBP. Meta-analysis was performed to pool the effects sizes across studies using a random-effect model if heterogeneity was present; otherwise, a fixed-effect model was used. Heterogeneity was assessed by Q test and I2. All studies were assessed with their quality and publication bias. Seventy-three studies with the mean age of 48.5 years were included. Our results indicated high NC have 1.95 (1.31, 2.89) and 2.08 (1.23, 3.52) times higher odds of T2D than low NC among females and males, respectively. For, HT the pooled ORs (95% CI) were 1.88 (1.36, 2.58) and 1.63 (1.26, 2.11) for females and males, respectively. Each 1 cm rising in NC would increase the odds of having T2D and HT in both genders by almost 1.2 and 1.1 respectively. In addition, the unstandardized mean difference of NC was about 1.3 cm higher in T2D and HT than non-T2D and non-HT. Furthermore, we found a positive correlation of NC with FBS, HBA1c, SBP, and DBP in both genders. Finding should be upraised with caution due to high heterogeneity even after subgroup analysis in some cases. More future prospective cohort studies will need to prove and simplify the association.
Description
Medical Epidemiology (Mahidol University 2020)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Medicine Ramathibodi Hospital
Degree Discipline
Medical Epidemiology
Degree Grantor(s)
Mahidol University