Jaroensawang W., Chongtrakool P., Chayakulkeeree M., Jitmuang A. A breakthrough invasive Aspergillus granulosus infection following azole antifungal therapy in a patient with primary myelofibrosis: case report. Medical Mycology Case Reports Vol.52 (2026). doi:10.1016/j.mmcr.2026.100782 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115848
Title
A breakthrough invasive Aspergillus granulosus infection following azole antifungal therapy in a patient with primary myelofibrosis: case report
Invasive aspergillosis (IA) primarily affects immunocompromised patients, with Aspergillus granulosus being a rare cause. Most cases occur in transplant recipients, and breakthrough infections may develop after azole therapy due to cryptic species and antifungal resistance. Here, we present the first non-transplant case of breakthrough A. granulosus infection following azole therapy with a fatal outcome. This case highlights the importance of early diagnosis, accurate species identification, and appropriate antifungal treatment for breakthrough invasive fungal infections.
